Isu tinoshandisa makuki kuvandudza ruzivo rwako. Nekuramba uchitsvaga saiti ino, unobvuma kushandisa kwedu makuki. Mamwe mashoko.
Nekudzvanya "Bvumira Zvese", unobvuma kuchengetwa kwemakuki pachishandiso chako kuti uwedzere kutenderera kwesaiti, kuongorora mashandisirwo esaiti, uye kutsigira kupihwa kwedu kwemahara, yakavhurika yesainzi zvemukati. Mamwe mashoko.
Muchidzidzo chechangobva kuitika chakabudiswa mupepanhau Pharmaceutics, vatsvakurudzi vakasarudza kushanda kweantimicrobial yemishonga yemakwenzi inonzi FRO kurwisa acne pathogenesis.
Antimicrobial evaluation uye in vitro ongororo yakaratidza kuti FRO ine yakakosha antibacterial uye anti-kuzvimba mhedzisiro kurwisa Dermatobacillus Acnes (CA), bhakitiriya rinokonzera mburwa. Mhedzisiro iyi inoratidza kushandiswa kwayo kwakachengeteka uye kwechisikigo mukurapa kweacne, kutsigira kushandiswa kwezvisina chepfu uye zvisingadhuri dzimwe nzira dzemishonga yemazuva ano.
Chidzidzo: Kubudirira kweFRO mune pathogenesis yeacne vulgaris. Mufananidzo wechikwereti: Steve Jungs/Shutterstock.com
Acne vulgaris, inowanzozivikanwa semapundu, chirwere cheganda chinowanzokonzerwa nebvudzi rakavharika rine sebum uye masero eganda akafa. Mapundu anobata vanopfuura 80 muzana yevachiri kuyaruka uye, kunyange zvazvo asingaurayi, anogona kukonzera kushungurudzika mupfungwa uye, mumatambudziko akaoma, ganda rinogara richiita pigmentation uye mavanga.
Acne inokonzerwa nekudyidzana kwemajini uye zvakatipoteredza, kazhinji zvinokonzerwa nekuchinja kwehomoni kunoperekedza kuyaruka panguva yekuyaruka. Uku kusaenzana kwehomoni kunowedzera sebum kugadzirwa uye kuwedzera insulin kukura factor 1 (IGF-1) uye dihydrotestosterone (DHT) basa.
Kuwedzera sebum secretion inoonekwa sedanho rekutanga mukukura kweacne, sezvo vhudzi rebvudzi rakazadzwa nesebum rine huwandu hukuru hwema microorganisms akadai SA. SA chinhu chakasikwa commensal chinhu cheganda; zvisinei, kuwedzera kuwanda kweiyo phylotype IA1 kunokonzera kuzvimba uye kuva nemavara emvere dzebvudzi nemapules anooneka kunze.
Kune zvakasiyana-siyana zvekuzora kurapa mburwa, senge retinoids uye topical microbial agents, inoshandiswa pamwe chete nemakemikari peels, laser/light therapy, uye mahormone agents. Zvisinei, kurapa uku kunodhura uye kunobatanidzwa nemigumisiro yakaipa.
Zvidzidzo zvakapfuura zvakaongorora mishonga yemakwenzi senzira inodhura yakasarudzika kune idzi marapirwo. Seimwe nzira, Rhus vulgaris (RV) zvinyorwa zvakadzidzwa. Zvisinei, kushandiswa kwayo kunogumira neurushiol, chinhu chinokosha cheallergenic chemuti uyu.
FRO imishonga yemakwenzi ine zvakaviriswa zvakatorwa zveRV (FRV) uye Japanese mangosteen (OJ) muchiyero che1:1. Kushanda kwefomula kwakaedzwa uchishandisa in vitro assays uye antimicrobial properties.
Musanganiswa weFRO wakatanga kuratidzwa uchishandisa yakakwira performance liquid chromatography (HPLC) kupatsanura, kuona uye kuenzanisa zvikamu zvayo. Musanganiswa wacho wakazoongororwazve kune yakazara phenolic content (TPC) kuona makomisheni angangove ane antimicrobial properties.
Preliminary in vitro antimicrobial assay nekuongorora disc diffusion senitivity. Kutanga, CA (phylotype IA1) yakanyatsogadzirwa pane imwe agar plate pairi 10 mm dhayamita FRO-impregnated filter paper disk yakaiswa. Basa reAntimicrobial rakaongororwa nekuyera ukuru hwenzvimbo inodzivirira.
Kubudirira kweFRO paCA-induced sebum kugadzirwa uye DHT-yakabatana androgen surges yakaongororwa uchishandisa Oil Red staining uye Western blot analysis, zvichiteerana. FRO yakazoedzwa kuti inokwanisa kumisa mhedzisiro yeiyo reactive oxygen marudzi (ROS), ayo anokonzera acne-associated hyperpigmentation uye post-kuvhiya mavanga, vachishandisa 2',7′-dichlorofluorescein diacetate (DCF-DA) probe. chikonzero.
Mhedzisiro yedhisiki diffusion yekuedza yakaratidza kuti 20 μL yeFRO yakabudirira inhibited CA kukura uye yakagadzira inooneka inhibition zone ye13 mm pakusangana kwe100 mg/mL. FRO inodzvinyirira zvakanyanya kuwedzera kwe sebum secretion inokonzerwa neSA, nekudaro inonotsa kana kudzoreredza kuitika kweacne.
FRO yakawanikwa ichipfuma mu phenolic compounds zvinosanganisira gallic acid, kaempferol, quercetin uye fisetin. Yese phenolic compound (TPC) inosvika 118.2 mg gallic acid yakaenzana (GAE) pagiramu FRO.
FRO yakanyanya kuderedza kuzvimba kweserura kunokonzerwa neSA-induced ROS uye kuburitswa kwecytokine. Kuderedzwa kwenguva refu mukugadzirwa kweROS kunogona kuderedza hyperpigmentation uye mavanga.
Kunyange zvazvo mishonga yedermatological yeacne iripo, inowanzodhura uye inogona kuva nemigumisiro yakawanda isingadiwi.
Mhedzisiro yacho inoratidza kuti FRO ine antibacterial properties inopesana neCA (mabhakitiriya anokonzera mburwa), zvichiratidza kuti FRO yakasikwa, isina chepfu uye inodhura imwe nzira yekurapa kwechinyakare mburwa. FRO zvakare inoderedza kugadzirwa kwesebum uye mahormone kutaura mu vitro, ichiratidza kushanda kwayo mukurapa nekudzivirira acne flare-ups.
Yakapfuura FRO miyedzo yemakiriniki yakaratidza kuti vanhu vanoshandisa FRO's advanced toner uye lotion vakawana kuvandudzwa kweganda elasticity uye hunyoro mazinga zvichienzaniswa neboka rekutonga mushure memavhiki matanhatu chete. Kunyange zvazvo chidzidzo ichi chisina kuongorora acne pasi pekutonga in vitro mamiriro, zvigumisiro zvemazuva ano zvinotsigira zvavakawana.
Zvakatorwa pamwechete, izvi zvigumisiro zvinotsigira kushandiswa kweramangwana kweFRO mukurapa kwekuzora, kusanganisira kurapwa kweacne uye kugadzirisa hutano hweganda.
Ichi chinyorwa chakagadziridzwa muna Chikumi 9, 2023 kutsiva mufananidzo mukuru neicho chakakodzera.
Yakatumirwa mu: Medical Science News | Medical Research News | Disease News | Nhau dzemishonga
Tags: mburwa, vechidiki, androgens, anti-kuzvimba, maseru, chromatography, cytokines, dihydrotestosterone, kushanda zvakanaka, kuvirisa, genetics, kukura zvinhu, bvudzi, mahormone, hyperpigmentation, in vitro, kuzvimba, insulin, phototherapy, liquid chromatography, okisijeni, kuwedzera , quercetin , retinoids, ganda, masero eganda, pigmentation yeganda, Western blot
Hugo Francisco de Souza munyori wesainzi anogara muBangalore, Karnataka, India. Zvido zvake zvedzidzo zviri muminda yebiogeography, evolutionary biology uye herpetology. Parizvino ari kuita dissertation yake yedoctoral. kubva kuCentre for Environmental Sciences kuIndia Institute of Science, kwaanodzidza kwaakabva, kugoverwa uye fungidziro yenyoka dzemumvura. Hugo akapiwa DST-INSPIRE Fellowship nokuda kwekutsvakurudza kwake kwechiremba uye Menduru yeGoridhe kubva kuPondicherry University nokuda kwekubudirira kwake mune zvidzidzo panguva yezvidzidzo zvaTenzi wake. Tsvagiridzo yake yakatsikiswa mumagazini akanyanya-anotariswa nevezera anosanganisira PLOS Neglected Tropical Diseases uye Systems Biology. Paanenge asiri kushanda nekunyora, Hugo anodya matani eanime nemakomiki, anonyora uye anonyora mimhanzi pagitare rebass, shreds tracks paMTB, anotamba mitambo yemavhidhiyo (anofarira izwi rekuti "mutambo"), kana kurira nechero chinhu. . michina.
Francisco de Souza, Hugo. (Chikunguru 9, 2023). Musanganiswa wakasiyana-siyana wezvinomera zvezvirimwa unopa zvine simba anti-acne mabhenefiti. Nhau – Kurapwa. Yakadzorerwa Gunyana 11, 2023, kubva https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Musanganiswa wakasarudzika wezvidyarwa zvine simba rekurwisa acne." Nhau – Kurapwa. Gunyana 11, 2023 .
Francisco de Souza, Hugo. "Musanganiswa wakasarudzika wezvidyarwa zvine simba rekurwisa acne." Nhau – Kurapwa. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Yakasvika munaGunyana 11, 2023).
Francisco de Souza, Hugo. 2023. Musanganiswa wakasiyana-siyana wezvinomera zvinomera zvine simba rinopesana neacne properties. News Medical, yakasvika Gunyana 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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