Tinoshandisa makuki kuti tivandudze ruzivo rwenyu. Nekuramba muchitsvaga saiti ino, munobvuma kushandisa kwedu makuki. Ruzivo rwakawanda.
Nekudzvanya "Bvumira Zvese", unobvuma kuchengetwa kwemakuki pamudziyo wako kuti uvandudze kufamba kwewebhusaiti, kuongorora kushandiswa kwewebhusaiti, uye kutsigira kupa kwedu zvemukati zvesainzi zvemahara uye zvakavhurika. Ruzivo rwakawanda.
Muongororo yakabudiswa munguva pfupi yapfuura mumagazini yePharmaceutics, vaongorori vakaona kushanda kwemushonga wemishonga unonzi FRO kurwisa hutachiona hwemapundu.
Kuongororwa kwemishonga inorwisa utachiona uye kuongororwa kwemishonga inorwisa mabhakitiriya mumuviri kwakaratidza kuti FRO ine simba guru rekurwisa mabhakitiriya uye kuzvimba pakurwisa Dermatobacillus Acnes (CA), bhakitiriya rinokonzera mapundu. Izvi zvinoratidza kushandiswa kwayo kwakachengeteka uye kwechisikigo mukurapa mapundu, zvichitsigira kushandiswa kwemishonga isiri chepfu uye inodhura zvishoma pane mishonga yemazuva ano yemapundu.
Chidzidzo: Kushanda kweFRO mukurwisa acne vulgaris. Mufananidzo wakapihwa naSteve Jungs/Shutterstock.com
Mapundu eganda, anozivikanwa semapundu, chirwere chinowanzoitika paganda chinokonzerwa nekuvhara bvudzi rine sebum nemasero eganda akafa. Mapundu anokanganisa vanopfuura 80 muzana vevechidiki uye, kunyange zvazvo asingauraye, anogona kukonzera kushungurudzika kwepfungwa uye, muzviitiko zvakakomba, ruvara rweganda rusingaperi uye mavanga.
Mapundu anokonzerwa nekubatana kwemajini nezvinhu zviri munharaunda, zvinowanzokonzerwa nekuchinja kwemahormone kunoitika panguva yekuyaruka. Kusarongeka kwemahormone uku kunowedzera kugadzirwa kwe sebum uye kuwedzera insulin growth factor 1 (IGF-1) uye dihydrotestosterone (DHT).
Kuwedzera kwekubuda kwe sebum kunoonekwa sedanho rekutanga mukukura kwemapundu, sezvo ma follicle ebvudzi azere ne sebum ane huwandu hwakawanda hwetupukanana twakaita seSA. SA chinhu chepanyama chinowanikwa muganda; zvisinei, kuwedzera kwe phylotype IA1 yayo kunokonzera kuzvimba uye kushanduka kwemavara ebvudzi nepapules dzinoonekwa kunze.
Kune nzira dzakasiyana-siyana dzekurapa mapundu, dzakadai se retinoids uye mishonga yekudzivirira utachiona, inoshandiswa pamwe chete ne chemical peels, laser/light therapy, uye mishonga yehomoni. Zvisinei, mishonga iyi inodhura zvakanyanya uye ine migumisiro yakaipa.
Zvidzidzo zvekare zvakaongorora mishonga yemiti senzira yechisikigo inodhura zvishoma pane iyi mishonga. Seimwe nzira, mishonga yeRhus vulgaris (RV) yakaongororwa. Zvisinei, kushandiswa kwayo kwakaganhurirwa neurushiol, chinhu chikuru chinokonzera allergies mumuti uyu.
FRO imhando yemishonga ine zvakatorwa kubva muRV (FRV) neJapanese mangosteen (OJ) zvakaviriswa muchikamu che1:1. Kushanda kwemhando iyi kwakaedzwa uchishandisa nzira dzekuongorora mu vitro uye hunhu hwehutachiona.
Musanganiswa weFRO wakatanga kutsanangurwa uchishandisa high performance liquid chromatography (HPLC) kuti uparadzanise, uone uye uverenge zvikamu zvawo. Musanganiswa uyu wakaongororwazve kuti uwane huwandu hwe phenolic (TPC) kuti uone makemikari angangove ane hunhu hwekuuraya utachiona.
Kuongororwa kwekutanga kwemishonga inorwisa utachiona mu vitro kuburikidza nekuongorora kunzwisisika kwekupararira kwediski. Chekutanga, CA (phylotype IA1) yakakurirwa zvakaenzana pandiro yeagar iyo yakaiswa dhisiki repepa rekusefa rine dhayamita ye10 mm FRO. Basa rekurwisa utachiona rakaongororwa nekuyera saizi yenzvimbo inodzivirira.
Kushanda kweFRO pakugadzirwa kwe sebum induced CA uye DHT-associated androgen surges kwakaongororwa uchishandisa Oil Red staining uye Western blot analysis, zvichiteerana. FRO yakazoongororwa kuti inokwanisa here kubvisa migumisiro ye reactive oxygen species (ROS), iyo inokonzera acne-associated hyperpigmentation uye post-surgical scars, uchishandisa 2′,7′-dichlorofluorescein diacetate (DCF-DA) probe.
Mhedzisiro yekuyedza kupararira kwemadisk yakaratidza kuti 20 μL yeFRO yakabudirira kudzivirira kukura kweCA uye yakagadzira nzvimbo inooneka yekudzivirira ye13 mm pahuwandu hwe100 mg/mL. FRO inoderedza zvakanyanya kuwedzera kwekuburitswa kwesebum kunokonzerwa neSA, nokudaro ichideredza kana kudzora kuitika kwemapundu.
FRO yakawanikwa iine huwandu hwakawanda hwe phenolic compounds dzinosanganisira gallic acid, kaempferol, quercetin uye fisetin. Huwandu hwe phenolic compound (TPC) hwaive paavhareji ye118.2 mg gallic acid equivalents (GAE) pa gramu FRO.
FRO yakaderedza zvakanyanya kuzvimba kwemasero kunokonzerwa neSA-induced ROS uye kuburitswa kwe cytokine. Kudzikira kwenguva refu kwekugadzirwa kweROS kunogona kuderedza hyperpigmentation uye mavanga.
Kunyange zvazvo kurapwa kweganda neganda kuripo, kazhinji kunodhura uye kunogona kuva nemigumisiro yakawanda isingadiwe.
Zvakabuda zvinoratidza kuti FRO ine simba rekurwisa mabhakitiriya eCA (mabhakitiriya anokonzera mapundu), zvichiratidza kuti FRO inzira yechisikigo, isina chepfu uye inodhura zvishoma pane mishonga yechinyakare yemapundu. FRO inoderedzawo kugadzirwa kwesebum uye kugadzirwa kwemahormone mu vitro, ichiratidza kushanda kwayo mukurapa nekudzivirira kuputika kwemapundu.
Miedzo yekiriniki yeFRO yapfuura yakaratidza kuti vanhu vanoshandisa toner nelotion yepamusoro yeFRO vakaona kuvandudzwa kukuru mukusimba kweganda uye mwero wehunyoro zvichienzaniswa neboka revanoongorora mushure memavhiki matanhatu chete. Kunyangwe chidzidzo ichi chisina kuongorora mapundu pasi pemamiriro ekudzora emushonga wekudzivirira ganda, mhedzisiro yazvino inotsigira zvavakawana.
Kana zvabatanidzwa, mhedzisiro iyi inotsigira kushandiswa kweFRO mune ramangwana mukurapa kumeso, kusanganisira kurapa mapundu uye kuvandudza hutano hweganda.
Chinyorwa ichi chakagadziriswa musi wa9 Chikumi, 2023 kuti chitsive mufananidzo mukuru newakakodzera.
Zvakanyorwa mu: Nhau dzeSainzi yezvekurapa | Nhau dzeKutsvagurudza kwezvekurapa | Nhau dzeZvirwere | Nhau dzeMishonga
Matagi: mapundu, vechidiki, androgens, anti-inflammatory, masero, chromatography, cytokines, dihydrotestosterone, efficiency, fermentation, genetics, growth factors, hair, hormones, hyperpigmentation, in vitro, inflammation, insulin, phototherapy, liquid chromatography, oxygen, proliferation, quercetin, retinoids, skin, skin cells, skin pigmentation, Western blot
Hugo Francisco de Souza munyori wesainzi anogara kuBangalore, Karnataka, India. Zvaanofarira muzvidzidzo zvake zviri muminda ye biogeography, evolutionary biology uye herpetology. Pari zvino ari kushanda padhigirii rake re doctorate kubva kuCenter for Environmental Sciences kuIndian Institute of Science, kwaanodzidza mavambo, kupararira uye kupatsanurwa kwenyoka dzemunzvimbo dzakaoma. Hugo akapihwa DST-INSPIRE Fellowship nekuda kwekutsvagisa kwake doctorate uye Gold Medal kubva kuPondicherry University nekuda kwekubudirira kwake muzvidzidzo zvake panguva yezvidzidzo zvake zveMasters. Tsvagiridzo yake yakaburitswa mumajenari ane simba guru anosanganisira PLOS Neglected Tropical Diseases uye Systems Biology. Paanenge asiri kushanda uye kunyora, Hugo anofarira anime yakawanda nemakomiki, anonyora uye anonyora mimhanzi pagitare rebass, anocheka nziyo paMTB, anotamba mitambo yemavhidhiyo (anofarira izwi rekuti "mutambo"), kana kugadzira matekinoroji chero api zvawo.
Francisco de Souza, Hugo. (Chikunguru 9, 2023). Musanganiswa wakasiyana wezvinotorwa mumiti unopa mabhenefiti ane simba ekurwisa mapundu. Nhau - Zvekurapa. Yakatorwa Gunyana 11, 2023, kubva ku https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Musanganiswa wakasiyana wezvinotorwa mumiti zvine simba rekurwisa mapundu." Nhau - Zvekurapa. Gunyana 11, 2023.
Francisco de Souza, Hugo. "Musanganiswa wakasiyana wezvinotorwa mumiti zvine simba rekurwisa mapundu." Nhau - Zvekurapa. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Yakasvikwa Gunyana 11, 2023).
Francisco de Souza, Hugo. 2023. Musanganiswa wakasiyana wezvinotorwa mumiti zvine simba rekurwisa mapundu. News Medical, yakasvikwa musi wa11 Gunyana, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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