Rutinkemikari formula ndeye (C27H30O16 • 3H2O), vhitamini, ine mhedzisiro yekudzikisa capillary permeability uye brittleness, kuchengetedza uye kudzorera yakajairika elasticity yecapillaries. Nekudzivirira uye kurapwa kwe hypertensive cerebral haemorrhage; Diabetic retinal hemorrhage uye hemorrhagic purpura inoshandiswawo sechikafu antioxidants uye pigment.

Iro rakakamurwa muzvikamu zvina zvinotevera:

1. Rutin NF11: yero-girini poda, kana yakanyatsonaka acicular crystal; Haina kunhuwa, isina kunaka; Ruvara runosviba mumhepo; Kupisa kusvika 185-192 ℃, inova yebrown gelatinous muviri uye inoora panosvika 215 ℃. Kunyungudika zvishoma mukubikisa ethanol, kunyungudika zvishoma mumvura iri kufashaira, kunyungudika zvishoma mumvura inotonhora, kunyungudika nyore muisopropyl alcohol uye methanol, isinganyunguriki mu trichloromethane, ether uye benzene; Soluble mu alkali hydroxide solution. Nzira yekuzivisa ndeye A: hydrochloric acid reflux hydrolysis kune quercetin, iyo nzvimbo yekunyungudika iri 312 ℃B: tsvuku cuprous oxide precipitation. C: Kuwedzera sodium hydroxide solution ndeyeorenji yero D: mushonga we ethanol uye ferric chloride mhinduro ine girini yebrown E: mushonga we ethanol une hydrochloric acid uye magnesium zvishoma nezvishoma zvitsvuku zvemukati: ≥95.0%(UV)(nezvigadzirwa zvakaoma)

Dry uremu kurasikirwa: 5.5% ~ 9.0%

Kupisa kwasara ≤0.5%

Chlorophyll ≤0.004%

Red pigment ≤0.004%

Zvinhu zvinoenderana nequercetin ≤5.0%(UV)

Huwandu hwehuwandu hwehutachiona hweaerobic ≤103cfu/g

Nhamba yese ye mold uye mbiriso ≤102cfu/g

Escherichia coli haigoni kuonekwa /g

Mamiriro ekuchengetedza Chengeta mumudziyo usingapindi mhepo kure nechiedza.

2. Rutoside Trihydrate EP 9.0: Yero kana yero-yegirini hupfu. Inenge isinganyungudika mumvura, inonyungudika mumethanol, inonyungudika zvishoma mu ethanol (96%), inenge isinganyunguriki mumethylene chloride. Soluble mu hydroxide solution. Nzira yekuziva ndeiyi inotevera: A: Yakanyanya kunyura pa257nm uye 358nm, uye yakanyanya absorption coefficient pa358nm ndeye 305 ~ 330. saizi ichaonekwa panzvimbo inoenderana yechromatogram yereferensi chigadzirwa D: ethanol mhinduro ine hydrochloric acid uye zinc icharatidza tsvuku.

Zviri mukati 95.0% ~ 101.0% (nechigadzirwa chakaoma)(titration)

Hunyoro 7.5% ~ 9.5% (Cartesian)

Kupisa kwasara ≤0.1%

Iyo yakanyanya kunyura mwenje kukosha kwehutsvina hwemaziso pa450nm kusvika 800nm ​​haifanire kunge yakakura kupfuura 0.10

Insoluble matter mu methanol ≤3.0%

Zvinhu zvinoenderana neisoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, tsvina yese ≤4.0%(HPLC)

Huwandu hwehuwandu hwehutachiona hweaerobic ≤104cfu/g

Nhamba yese ye mold uye mbiriso ≤102cfu/g

Bile gram-negative mabhakitiriya ≤102cfu/g

Escherichia coli haigoni kuonekwa /g

Salmonella inogona kusaonekwa / 25g

Mamiriro ekuchengetedza anoramba ari kure nechiedza

3. Rutin USP43: Nzira yekuzivikanwa ndeye A: yakanyanya kunyura pa 257nm uye 358nm, uye yakanyanya kunyura coefficient pa 358nm ndeye 305 ~ 33. B: Iyo infrared absorption spectra inofanira kuenderana nechromatogram yereferensi chigadzirwa. C: Nguva yekuchengeta yechromatogram peak inofanirwa kuenderana neiyo yereferensi chigadzirwa

Zviri mukati 95.0% ~ 101.0% (nechigadzirwa chakaoma)(titration)

Hunyoro 7.5% ~ 9.5% (Cartesian)

Kupisa kwasara ≤0.1%

Iyo yakanyanya kunyura mwenje kukosha kwehutsvina hwemaziso pa450nm kusvika 800nm ​​haifanire kunge yakakura kupfuura 0.10

Insoluble matter mu methanol ≤3.0%

Zvinhu zvinoenderana isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, mamwe mono-miscellaneous ≤1.0%, zvachose tsvina ≤4.0%(HPLC)

Huwandu hwehuwandu hwehutachiona hweaerobic ≤104cfu/g

Nhamba yese ye mold uye mbiriso ≤103cfu/g

Escherichia coli haigoni kuonekwa / 10g

Salmonella haigoni kuonekwa / 10g

Mamiriro ekuchengetedza akavharwa uye akachengetwa kure nechiedza.

4. Chiyero chehushumiri WS1-49(B)-89 cheRutinum: yero kana yero-girini poda, kana yakanakisa acicular crystal; Haina kunhuwa, isina kunaka; Ruvara runosviba mumhepo; Kupisa kusvika 185 ~ 192 ℃ kuti ive brown gel. Inonyungudika zvishoma mukubikisa ethanol, inonyungudika zvishoma mumvura iri kufashaira, inonyungudika zvishoma mumvura inotonhora, isinganyunguriki mu trichloromethane uye ether; Soluble mu alkali hydroxide solution. Nzira yekuziva ndeiyi: A: red cuprous oxide precipitate. B: Iyo infrared absorption pateni inofanirwa kuenderana neiyo yezvinhu inodzora. C: Kunyura kwakanyanya kunowanikwa pamasaisai e259±1nm uye 362.5±1nm.

Zvemukati ≥93.0%(UV)(nechigadzirwa chakaoma)

Dry uremu kurasikirwa 5.5% ~ 9.0%

Kupisa kwasara ≤0.3%

Insoluble nyaya mu methanol ≤2.5% (insoluble nyaya mu ethanol)

Inoenderana nechinhu quercetin ≤4.0%(Mutete mutsetse)

Huwandu hwehuwandu hwehutachiona hweaerobic ≤103cfu/g

Nhamba yese ye mold uye mbiriso ≤102cfu/g

Escherichia coli haigoni kuonekwa /g

Salmonella haigoni kuonekwa /g

Mamiriro ekuchengetedza akavharwa uye akachengetwa kure nechiedza.

Pharmacological effect:

Antifree radical action

Oxygen molecules inodzikiswa muchimiro chemaerekitironi ega mu cell metabolism, uye maO ions anogadzirwa nekudzikiswa kwemaokisijeni mamorekuru muchimiro chemaerekitironi ega anobva aburitsa H2O2 uye ine muchetura wakanyanya ·OH mahara radicals mumuviri, zvichikanganisa ganda. kutsetseka uye kunyange kukurumidza kuchembera kweganda. Uyezve, kuwedzera rutin kuchigadzirwa kunogona kubvisa zviripachena mhando yeokisijeni inogadzirwa nemasero. Rutin ikemikari yeflavonoid, inova yakasimba antioxidant yekubvisa mahara radicals. Inogona kumisa chain reaction yemahara radicals, inhibit peroxidation ye polyunsaturated fatty acids pane biofilms, kubvisa lipid peroxidation zvigadzirwa, kuchengetedza kuvimbika kwebiofilms uye subcellular zvimiro, uye kuita basa rakakosha mumuviri. [2]

Anti-lipid peroxidation

Lipid peroxidation inoreva nhevedzano yeoxidation maitiro anokonzerwa neiyo reactive oxygen mhando inorwisa polyunsaturated fatty acids mune biofilms. Zhu Jianlin et al. yakatsunga uye yakaongorora chiitiko cheSOD mumakonzo, zvirimo zvemahara-radical lipid peroxidation chigadzirwa MDA, uye zvirimo muLipofuscin muchiropa chikuru, uye akawana kuti rutin ine inhibitory mhedzisiro pa lipid peroxidation mumakonzo akadzingwa, uye inogona kutadzisa kuderera kweiyo antioxidant simba. ye antioxidant system mumakonzo mushure mekukandwa. Rutin inogona kuramba kuderera kweiyo antioxidant kugona kunokonzerwa nekudzikira kweesrogen endogenous uye ine antioxidant mhedzisiro. High density lipoprotein (HDL) ine anti-atherosclerotic mhedzisiro. Nekudaro, HDL, senge yakaderera density lipoprotein (LDL) uye yakaderera kwazvo density lipoprotein (VLDL), inogona zvakare kuve ne oxidized uye kugadziridzwa in vitro. Kamwe HDL yave oxidized uye yakagadziridzwa kuita Ox-HDL, ine mhedzisiro yeatherosclerosis. Meng Fang et al. yakaongorora mhedzisiro yerutin paHDL oxidative modification neCu2+ mediated oxidative modification in vitro. Mhedziso Rutin inogona kuvharisa zvakanyanya oxidative shanduko yeHDL. [2]

Antagonistic mhedzisiro yeplatelet activating factor

Iyo pathogenesis yezvirwere zvakawanda zvemoyo uye cerebrovascular, senge thrombosis, atherosclerosis, kuputika kwekuita uye ischemia-reperfusion mahara radical kukuvara, zvine hukama zvakanyanya nekuyananisa kweplateletactivatingfactor (PAF). Naizvozvo, kupokana nemhedzisiro yePAF inzira yakakosha yekudzikisa ischemic yemoyo uye cerebrovascular zvirwere. Ongororo dzakaratidza kuti rutin inogona kupikisa kusungirirwa chaiko kwePAF kune tsuro platelet membrane receptors inotsamira, inhibit PAf-mediated platelet adhesion mutsuro uye kuwedzera kwemahara Ca2 + kusungwa muPMNs, zvichiratidza kuti maitiro erutin's anti-PAF chiito ndeye kurambidza kushandiswa kwePAF receptor, uyezve kuvhara maitiro anokonzerwa nePAF, kuitira kuti uite basa mukudzivirira kwemwoyo. Mhedzisiro yacho yakaratidza kuti rutin aive PAF receptor antagonist. [2]

Anti-acute pancreatitis

Rutin inogona kudzivirira zvinobudirira hypocalcemia uye kuderedza Ca2 + concentration mupancreatic tissue. Yakawanikwa kuti rutin inogona kuwedzera zvinyorwa zvephospholipase A2 (PLA2) mupancreatic tissue yemakonzo, zvichiratidza kuti rutin inogona kudzivisa kusunungurwa uye kushandiswa kwePLA2 mupancreatic tissue. Rutin inogona kudzivirira zvinobudirira kuitika kwe hypocalcemia mu AP rats, zvichida nekudzivirira Ca2 + kuwedzera uye kuderedza Ca2 + kuwandisa mupancreatic tissue masero, nokudaro kuderedza kukuvara kwepathophysiological kuAP. [2]

Chirevo: https://mp.weixin.qq.com

https://xueshu.baidu.com/usercenter/paper

Kune rutin, ndapota taura nesu. Takakumirirai pano chero nguva.