Chirwere chegomarara remapapu ndicho chechipiri chemhando yegomarara rakajairika pasi rose. Muna 2020, vanhu vanopfuura mamirioni maviri nemazana maviri pasi rose vachabatwa nekenza yemapapu kekutanga. Mugore iroro, vanhu vanenge mamiriyoni 1,8 munyika yose vakafa nekenza yemapapu.
Nepo pari zvino pasina mushonga wegomarara remapapu, masayendisiti ari kushanda panzira dzekurapa. Mamwe emasayendisiti aya anoshanda paUniversity of Technology Sydney (UTS), uko ongororo itsva yakaratidza kuti chisikwa chechirimwa chinonzi berberine chinogona kumisa kukura kwekenza yemapapu murabhoritari.
Berberine musanganiswa wechirimwa unongoitika wagara uchishandiswa mumishonga yechivanhu yechiChinese kwezviuru zvemakore. Inowanikwa mumiti yakasiyana-siyana, kusanganisira barberry, goldenseal, Oregon mazambiringa, uye muti turmeric.

(Chigadzirwa chedu chiriBerberine Extract, tinokugamuchirai nemoyo wese kubvunza.)

Makore ekutsvagisa kwakaratidza kuti berberine inoshanda mukubatsira vanhu vane Type 2 chirwere cheshuga kudzora mazinga eshuga yeropa uye inogona kubatsira kurapa metabolic syndrome.
Vatsvagiri vakawanawo kuti berberine inogona kushandiswa kurapa akasiyana kenza, kusanganisira ovarian, dumbu, uye kenza yemazamu.
Sekureva kwaDr. Kamal Dua, Mudzidzisi Mukuru uye Senior Research Fellow muFarmacy paAustralia Research Center yeComplementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) Chikoro cheMishonga uye munyori anotungamirira wekudzidza, Berberine inhibits maviri anokosha. maitiro mukukura kwegomarara - Kuwedzera uye kutama kwesero.
“Nemichina, izvi zvinogona kuwanikwa nekuvharisa majini akakosha akadai seP53, PTEN neKRT18 uye mapuroteni akaita seAXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. uye CAPG yakabatana nekuwanda uye kutama kwemasero egomarara, ”akatsanangura.
Muchidzidzo chezvino, boka rekutsvakurudza rinosanganisira Dr. Dua, Dr. Keshav Raj Paudel, Purofesa Philip M. Hansbrough uye Dr. Bikash Manandhar weUTS, pamwe chete nevashandi vanobva kuMalaysian International Medical University uye Al Qasim University muSaudi Arabia, akadzidza kuti berberine inogona kushandiswa sei kurapwa kenza yemapapu.
"Kushandiswa kwekiriniki yeberberine kunogumira nekuda kwekusagadzikana kwayo uye bioavailability," akatsanangura Dr. Dua weMNT. "Chinangwa chikuru chechidzidzo ichi ndechekuvandudza physicochemical parameters yeberberine nekushandura berberine kuita liquid crystal nanoparticles uye kuongorora iyo anticancer inogona kuitika mu vitro paalveolar epithelial basal masero emunhu adenocarcinoma A549."
Chikwata chekutsvagisa chakagadzira advanced dhizaini sisitimu inoputira berberine mumadiki madiki anonyungudika uye biodegradable spheres. Aya emvura ekristaro nanoparticles akashandiswa kurapa masero ekenza yemapapu emunhu mu vitro murabhoritari.
Pakupera kwechidzidzo, boka racho rakaona kuti berberine yakabatsira kuvharidzira kugadzirwa kweiyo reactive oxygen marudzi, makemikari anopisa anogadzirwa nemamwe masero mukupindura kurwiswa kwebhakitiriya uye zvimwe zviitiko zvinoshungurudza zvinogona kukuvadza masero.
Pamusoro pezvo, berberine inobatsira kudzora majini ane chekuita neoxidative kusagadzikana uye kuzvimba, uye inobatsira kuderedza kuchembera kwesero nguva isati yakwana.
"Takaratidza kuti, tichishandisa nanotechnological approach, zvinhu zvekomboni zvinogona kuvandudzwa kugadzirisa nyaya dzakasiyana-siyana dzine chokuita nekunyungudika, kushandiswa kwemasero, uye kurapa kwakanaka," akatsanangura Dr. Dua. Anticancer Potential Yedu berberine liquid crystal nanoparticles yakaratidza chiitiko chimwe chete kashanu muyero uchienzaniswa nemabhuku akadhindwa, zvichinyatsoratidza mabhenefiti emananodrugs. "
Kuenderera mberi nekuyedza mhinduro idzi, Dr. Dua vakati vanoronga kushandisa tsvagiridzo nyowani kuita zvidzidzo zvakadzama vachishandisa mhando dzemhuka dzekenza yemapapu.
"Kumwezve mishonga yemishonga uye anticancer zvidzidzo zveberberine nanodrugs mumhando dzemhuka mu vivo zvinogona kuratidza zvingangobatsira mukurapa kenza yemapapu uye kuvashandura kuva maitiro ekurapa," akatsanangura kudaro.
"Kana tangosimbisa simba rinopesana nekenza yeberberine nanodrugs mumhando dzemhuka dzepreclinical, danho rinotevera richava rekuenda kumakiriniki ekuedzwa, izvo zvatiri kutokurukura nemakambani akawanda eSydney," akadaro Dr. Dua.
Mukuwedzera, Dr. Dua akataura kuti kukwanisa kweberberine kudzivirira kudzoka kwekenza yemapapu kunoda kusimbiswa: "Kunyangwe isu tisati taongorora izvi, tinoronga kuzvidzidza mune zvidzidzo zvenguva yemberi, uye tinotenda zvakare kuti berberine nanoforms icharatidza. basa rinovimbisa. “.
Dr. Osita Onuga, chiremba anovhiya thoracic uye mubatsiri purofesa wekuvhiya thoracic paSt. John Cancer Institute paProvidence St. John Medical Center muSanta Monica, California, akaudza MNT kuti kana vaongorori vakawana mikana mitsva yekurapa nekudzivirira cancer, pane nguva dzose. tariro:
"Berberine chikamu chemushonga wekuMabvazuva, saka isu hatiwanzoishandisa mukurapa kwekuMadokero. Ndinofunga kuti zvinonakidza nekuti tiri kutarisa izvo zvatinoziva zvine mabhenefiti ezvemishonga yekuMabvazuva zvinhu, uye tozviisa mukutsvagisa kuti zvibatsire kushandura izvozvo mukurapa kwekuMadokero. “.
"Zvinogara zvichivimbisa, asi zviri murabhoritari, uye zvakawanda zvatinowana mulabhu hazviiti kuti varwere varapwe," Onuga akaenderera mberi. "Ini ndinofunga chinhu chinotevera kuita kuita mimwe miedzo yekiriniki pavarwere uye kuona dosi."
Vamwe vanhu vanoona zviratidzo zvisingaoneki zvekenza yemapapu mumatanho ekutanga echirwere. Verenga kuti udzidze zvakawanda, kusanganisira nguva yekuona chiremba.
Gomarara remapapu rinoitika pamitengo yakasiyana muvakadzi nevarume, asi zviratidzo nenjodzi dzakafanana. Pano tinotsanangura zvinokwanisika genetic uye hormonal…
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