Gomarara remapapu ndiro rudzi rwechipiri rwakajairika rwegomarara pasi rose. Muna 2020, vanhu vanopfuura mamiriyoni 2.2 pasi rose vachaonekwa vaine gomarara remapapu kekutanga. Mugore rimwe chete iroro, vanhu vanosvika mamiriyoni 1.8 pasi rose vakafa negomarara remapapu.
Kunyange hazvo pari zvino pasina mushonga wegomarara remapapu, masayendisiti ari kushanda pakutsvaga nzira dzekurapa. Vamwe vemasayendisiti aya vanoshanda paYunivhesiti yeTekinoroji yeSydney (UTS), uko ongororo itsva yakaratidza kuti chinhu chechisikigo chinonzi berberine chinogona kumisa kukura kwemasero egomarara remapapu murabhoritari.
Berberine imusanganiswa wezvirimwa zvechisikigo zvave zvichishandiswa mumishonga yechivanhu yeChina kwezviuru zvemakore. Inowanikwa mumiti yakasiyana-siyana, kusanganisira barberry, goldenseal, Oregon grape, uye tree turmeric.

(Chigadzirwa cheduMushonga weBerberine, tinokugamuchirai nemwoyo wese kubvunzurudzo.)

Makore ekutsvaga akaratidza kuti berberine inoshanda mukubatsira vanhu vane chirwere cheshuga cherudzi rwechipiri kudzora huwandu hweshuga muropa ravo uye inogona kubatsira kurapa chirwere chemetabolic.
Vaongorori vakaonawo kuti berberine inogona kushandiswa kurapa mhando dzakasiyana dzekenza, kusanganisira kenza yemazamu, dumbu, uye mazamu.
Sekureva kwaDr. Kamal Dua, Senior Lecturer uye Senior Research Fellow muPharmacy paAustralian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) School of Medicine uye munyori mukuru wechidzidzo ichi, Berberine inodzivirira maitiro maviri akakosha mukukura kwegomarara - Kuwanda kwemasero uye kufamba kwemasero.
"Muchina, izvi zvinogona kuitwa nekudzivisa majini akakosha akadai seP53, PTEN neKRT18 uye mapuroteni akadai seAXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. uye CAPG zvine chekuita nekuwanda uye kutama kwemasero ekenza," akatsanangura.
Muchidzidzo chazvino, chikwata chekutsvagisa chinosanganisira Dr. Dua, Dr. Keshav Raj Paudel, Purofesa Philip M. Hansbrough naDr. Bikash Manandhar veUTS, pamwe nevashandi vekuMalaysian International Medical University neAl Qasim University muSaudi Arabia, vakadzidza kuti berberine ingashandiswa sei kurapa kenza yemapapu.
"Kushandiswa kweberberine mukiriniki hakugoneki nekuda kwekunyungudika kwayo uye kuwanikwa kwayo mumuviri," akatsanangura Dr. Dua weMNT. "Chinangwa chikuru chechidzidzo ichi ndechekuvandudza maparamita efizikisi yeberberine nekushandura berberine kuita nanoparticles dzekristaro yemvura uye kuongorora kugona kwayo kurwisa kenza mu vitro pamasero e alveolar epithelial basal emunhu adenocarcinoma A549."
Chikwata chevatsvagurudzi chakagadzira sisitimu yepamusoro yekupa mishonga inofukidza berberine muzvikamu zvidiki zvinonyungudika uye zvinoora. Izvi zvikamu zvidiki zvekristaro yemvura zvakashandiswa kurapa masero ekenza yemapapu emunhu murabhoritari.
Pakupera kwechidzidzo ichi, timu iyi yakawana kuti berberine yakabatsira kudzivirira kugadzirwa kwemhando dzeokisijeni dzinoshanda, makemikari anokonzera kuzvimba anogadzirwa nemamwe masero mukupindura kupinda kwebhakitiriya nezvimwe zviitiko zvinoshungurudza zvinogona kukuvadza masero.
Pamusoro pezvo, berberine inobatsira kudzora majini ane chekuita nekushushikana kwe oxidative uye kuzvimba, uye inobatsira kuderedza kukwegura kwemasero nguva isati yakwana.
"Taratidza kuti, tichishandisa nzira ye nanotechnology, hunhu hwemusanganiswa uyu hunogona kuvandudzwa kugadzirisa matambudziko akasiyana-siyana ane chekuita nekunyungudika, kutorwa kwemasero, uye kushanda zvakanaka kwekurapa," akatsanangura Dr. Dua. Kugona Kurwisa Kenza Berberine liquid crystal nanoparticles yedu yakaratidza chiitiko chimwe chete nekashanu pane dose kana tichienzanisa nemabhuku akabudiswa, zvichiratidza pachena mabhenefiti e nanodrugs."
Kuti vaedze zvakare zvabuda izvi, Dr. Dua vakati vanoronga kushandisa puratifomu itsva yekutsvagisa kuita zvidzidzo zvakadzama vachishandisa mhando dzegomarara remapapu dzemhuka dzisati dzaongororwa.
"Dzimwe ongororo dzemishonga uye dzekurwisa kenza dzeBerberine nanodrugs mumhando dzemhuka dziri mumuviri dzinogona kuratidza mabhenefiti adzo mukurapa kenza yemapapu uye kuashandura kuita mafomu ekurapa," akatsanangura.
"Kana tangosimbisa kugona kweBerberine nanodrugs kurwisa kenza mumhando dzemhuka dzisati dzaongororwa, danho rinotevera richave rekuenderera mberi nemiedzo yekiriniki, yatiri kutokurukura nemakambani akati wandei ekuSydney," akadaro Dr. Dua.
Pamusoro pezvo, Dr. Dua vakati mukana wekuti berberine idzivirire kudzoka kwekenza yemapapu unofanirwa kusimbiswa: "Kunyangwe tisati taongorora izvi, tinoronga kuzvidzidza muzvidzidzo zveramangwana, uye tinotendawo kuti berberine nanoforms icharatidza kushanda kwakanaka."
Dr. Osita Onuga, chiremba wechipfuva uye mubatsiri wepurofesa wekuvhiya chifuva paSt. John Cancer Institute paProvidence St. John Medical Center muSanta Monica, California, vakaudza MNT kuti kana vaongorori vakawana mikana mitsva yekurapa nekudzivirira kenza, pane tariro nguva dzose:
"Berberine chikamu chemishonga yekuMabvazuva, saka hatiishandise mumishonga yekuMabvazuva. Ndinofunga zvinonakidza nekuti tiri kutarisa zvatinoziva kuti zvine zvakanakira mishonga yekuMabvazuva, tozviisa muongororo kuti zvibatsire kushandura izvozvo mumishonga yekuMabvazuva."
"Zvinogara zvichivimbisa, asi zviri murabhoritari, uye zvakawanda zvatinowana murabhoritari hazviiti kuti varwere varapwe," Onuga akaenderera mberi. "Ndinofunga kuti chinhu chinotevera chekuita ndechekuedza varwere uye kuona kuti mushonga wacho unorapwa sei."
Vamwe vanhu vanowana zviratidzo zvisinganzwisisike zvegomarara remapapu pakutanga kwechirwere ichi. Ramba uchiverenga kuti udzidze zvakawanda, kusanganisira nguva yekuona chiremba.
Kenza yemapapu inoitika pamatanho akasiyana muvakadzi nevarume, asi zviratidzo nezvinhu zvinoisa njodzi zvakafanana. Pano tinotsanangura zvinogoneka zvemajini nemahormone…
Isu tiri nyanzvi mukugadzira hupfu hwezvinomera, tinokugamuchirai kuti tikutumirei mibvunzo nezvechigadzirwa chedu uye tine mushandi ane mutoro wekugadzirisa matambudziko enyu nezvezvinhu zvisati zvatengeswa uye zvapera kutengeswa. Tibatei Chero Nguva!!!