Pakati pemapepa achangoburwa pane iyi ine simba antioxidant wongororo yakaburitswa muPhytotherapy Research munaKurume 2019, iyo yakaongorora zvinhu zvipfumbamwe nezve mhedzisiro yequercetin pa metabolic syndrome Randomized controlled muyedzo.

Metabolic syndrome inoreva nhevedzano yematambudziko ehutano anowedzera njodzi yerudzi rwechipiri chirwere cheshuga, chirwere chemoyo, uye sitiroko, kusanganisira kukwira kweropa, shuga yeropa, yakakwira triglyceride, uye chiuno kuunganidzwa kwemafuta.

Kunyangwe ongororo dzakadzama dzakawana kuti quercetin haina chekuita nekutsanya kweglucose yeropa, insulin kuramba kana hemoglobin A1c mazinga, kumwe kuongorora kweboka kwakaratidza kuti quercetin yakawedzerwa mune zvidzidzo zvakatora kanenge 500 mg pazuva kweanenge mavhiki masere. Yakaderedzwa zvakanyanya kutsanya shuga yeropa.

Quercetin inobatsira kudzora gene kutaura

Zvinoenderana neongororo yakaburitswa muna 2016, quercetin inogona zvakare kumisikidza mitochondrial chiteshi cheapoptosis (yakarongwa sero kufa kwemasero akakuvadzwa) nekubatana neDNA, nekudaro zvichikonzera kudzoka kwebundu.

Zvidzidzo zvakawana kuti quercetin inogona kukurudzira cytotoxicity yemasero eukemia, uye mhedzisiro yacho ine chekuita nedosi. Yakaganhurirwa cytotoxic mhedzisiro yakawanikwa zvakare mumasero egomarara rezamu. Kazhinji, quercetin inogona kuwedzera hupenyu hwemakonzo egomarara ne5 nguva kana ichienzaniswa neboka risina kurapwa.

Vanyori vanoti izvi zvinokonzerwa nekubatana kwakananga pakati pequercetin neDNA uye kushandiswa kwayo kwemitochondrial nzira yeapoptosis, uye vanokurudzira kuti kushandiswa kwequercetin semushonga wekurapa kwegomarara kwakakodzera kuongororwa zvakare.

Ongororo ichangoburwa yakabudiswa mumagazini Molecules yakasimbisawo epigenetic mhedzisiro yequercetin uye kugona kwayo ku:

Kudyidzana nematanho ekunongedza masero
Regulate gene expression
Inokanganisa basa rezvinyorwa zvekunyora
Inogadzirisa microribonucleic acid (microRNA)

Microribonucleic acid yakamboonekwa se "junk" DNA. Ongororo dzakawana kuti “junk” DNA haina kana basa. Chaizvoizvo imorekuru diki re ribonucleic acid, iro rinoita basa rakakosha mukudzora majini anoita mapuroteni evanhu.

Microribonucleic acid inogona kushandiswa se "switch" yemajini aya. Zvinoenderana nekuiswa kwemicroribonucleic acid, jini rinogona kukodha chero pane zvinopfuura mazana maviri ezvigadzirwa zveprotein. Kugona kweQuercetin kugadzirisa microRNAs kunogonawo kutsanangura cytotoxic mhedzisiro uye nei ichiita kunge inowedzera kupona kwegomarara (kunyanya mbeva).

Quercetin ine simba antiviral ingredient

Sezvambotaurwa pamusoro, tsvakiridzo yakaitwa yakatenderedza quercetin inotarisa pane yayo antiviral kugona, izvo zvinonyanya kukonzerwa nematanho matatu ekuita:

Kudzivisa kukwanisa kwemavhairasi kukanganisa masero
Kudzivisa kudzokororwa kwemasero ane utachiona
Deredza kupikisa kwemasero ane utachiona kune antiviral drug treatment

Semuenzaniso, chidzidzo chakatsigirwa neDhipatimendi reDziviriro reUnited States chakaburitswa muna 2007 chakawana kuti mushure mekusangana nekushushikana kwakanyanya kwemuviri, quercetin inogona kuderedza njodzi yako yekutapukirwa nehutachiona uye kugadzirisa mashandiro ako epfungwa, zvikasadaro inogona kukuvadza immune system yako, Ichiita kuti uwedzere kubatwa nehutachiona. kuzvirwere.

Muchidzidzo ichi, vatyairi vemabhasikoro vakagamuchira 1000 mg yequercetin pazuva, yakasanganiswa nevhitamini C (inowedzera plasma quercetin mazinga) uye niacin (inokurudzira kunwa) kwemavhiki mashanu akatevedzana. Zvigumisiro zvakawana kuti zvichienzaniswa neasina kurapwa Kune chero mutyairi webhasikoro akarapwa, avo vakatora quercetin vaiva nemukana wakaderera zvikuru wekubatwa nehutachiona hwehutachiona mushure mekutasva bhasikoro kwemaawa matatu pazuva kwemazuva matatu akatevedzana. 45% yevanhu vari muboka re placebo vairwara, asi 5% chete yevanhu vaiva muboka rekurapa vairwara.

Sangano reUS Defence Advanced Research Projects Agency (DARPA) rakapa mari imwe ongororo, iyo yakatsikiswa muna 2008, uye ikadzidza kushandiswa kweutachiona hwefuruwenza H1N1 hwakanyanya kupikisa mhuka dzinorapwa nequercetin. Chigumisiro chichiri chakafanana, kurwara uye kufa kweboka rekurapa kwaive kwakaderera kudarika kweboka re placebo. Zvimwe zvidzidzo zvakasimbisawo kushanda kwequercetin kurwisa mavhairasi akasiyana, anosanganisira:

Ongororo yakaitwa muna 1985 yakawana kuti quercetin inogona kutadzisa kutapukira uye kudzokorora kweherpes simplex virus type 1, poliovirus type 1, parainfluenza virus type 3, uye kufema syncytial virus.

Imwe ongororo yemhuka muna 2010 yakawana kuti quercetin inogona kuvharidzira ese mavhairasi efuruwenza A neB. Panewo zvinhu zviviri zvikuru zvakawanikwa. Kutanga, mavhairasi aya haakwanisi kukurira kurwisa quercetin; chechipiri, kana yakashandiswa pamwe chete nemishonga inorwisa mabhakitiriya (amantadine kana oseltamivir), migumisiro yavo inowedzera zvakanyanya-uye kukura kwekudzivirira kunodziviswa.

Chidzidzo chemhuka muna 2004 chakabvumidza kuomarara kwehutachiona hweH3N2, ichiongorora mhedzisiro yequercetin pafuruwenza. Munyori akati:

"Munguva yehutachiona hwehutachiona hwehutachiona, oxidative stress inoitika. Nokuti quercetin inogona kudzorera kusangana kwevakawanda antioxidants, vamwe vanhu vanofunga kuti inogona kuva mushonga unoshanda unogona kudzivirira mapapu kubva pakusunungurwa panguva yehutachiona hwehutachiona. Izvo zvinokuvadza zveokisijeni pasina radicals. "

Imwe ongororo ya2016 yakawana kuti quercetin inogona kudzora mapuroteni kutaura uye ine inodzivirira pahutachiona hweH1N1 furuwenza. Kunyanya, kudzora kupisa kunotyisa protein, fibronectin 1 uye inhibitory protein inobatsira kudzikisa hutachiona.

Chidzidzo chechitatu chakaburitswa muna 2016 chakawana kuti quercetin inogona kuvharisa marudzi akasiyana efuruwenza, anosanganisira H1N1, H3N2, uye H5N1. Munyori weshumo yekutsvagisa anotenda kuti, "Chidzidzo ichi chinoratidza kuti quercetin inoratidza inhibitory chiitiko mukutanga kwehutachiona hwefuruwenza, iyo inopa hurongwa hweramangwana rekurapa kuburikidza nekugadzirwa kwemishonga inoshanda, yakachengeteka, uye isingadhure yekurapa nekudzivirira [Influenza. Utachiona] hutachiona."

Muna 2014, vatsvakurudzi vakaratidza kuti quercetin "inoratidzika kuva inovimbisa mukurapa zvirwere zvinowanzoitika zvinokonzerwa nerhinoviruses" uye akawedzera, "Tsvakurudzo yakasimbisa kuti quercetin inogona kuderedza kushandiswa kwemukati uye kudzokorora kwehutachiona mu vitro. Muviri unogona kuderedza hutachiwana, mabayo uye kufambisa mhepo kwemhepo."

Quercetin inogonawo kuderedza kukuvadzwa kweoxidative, nokudaro kuderedza ngozi yehutachiona hwehutachiona hwechipiri, iyo ndiyo inonyanya kukonzera kufa kwefuruwenza. Zvakakosha, quercetin inowedzera mitochondrial biosynthesis mune skeletal tsandanyama, zvichiratidza kuti chikamu cheiyo antiviral mhedzisiro inokonzerwa nekuwedzerwa mitochondrial antiviral chiratidzo.

Chidzidzo chemhuka muna 2016 chakawana kuti quercetin inogona kuvharidzira dengue hutachiona uye hutachiona hwehutachiona hwehutachiona mumakonzo. Zvimwe zvidzidzo zvakasimbisawo kuti quercetin ine simba rekudzivisa utachiona hwehepatitis B neC.

Munguva pfupi yapfuura, ongororo yakaburitswa mujenari Microbial Pathogenesis munaKurume 2020 yakawana kuti quercetin inogona kupa dziviriro yakazara kubva kuStreptococcus pneumoniae kutapukira zvese mu vitro uye muvivo. Chepfu (PLY) inoburitswa nepneumococcus kudzivirira kubuda kweStreptococcus pneumoniae infection. Mumushumo we "Microbial Pathogenesis", munyori akati:

"Zvigumisiro zvinoratidza kuti quercetin inonyanya kuderedza basa rehemolytic uye cytotoxicity inokonzerwa nePLY nekudzivisa kuumbwa kwemaoligomers.
Mukuwedzera, kurapwa kwequercetin kunogonawo kuderedza PLY-mediated cell kukuvara, kuwedzera chiyero chekupona kwemakonzo ane hutachiona hweStreptococcus pneumoniae, kuderedza kukuvadzwa kwemapapu, uye inhibit cytokines (IL-1β uye TNF) mubronchoalveolar lavage fluid. -α) kusunungurwa.
Tichifunga nezvekukosha kwezviitiko izvi muhutachiona hwehutachiona hweStreptococcus pneumoniae, zvigumisiro zvedu zvinoratidza kuti quercetin inogona kuva mutsva wemishonga inoshandiswa pakurapa kwechirwere chepneumococcal. "
Quercetin inorwisa kuzvimba uye inowedzera immune function

Mukuwedzera kune antiviral chiitiko, quercetin inogona zvakare kuwedzera kusadzivirirwa uye kurwisa kuzvimba. Chidzidzo che2016 chakabudiswa mumagazini Nutrients chakaratidza kuti nzira dzekuita dzinosanganisira (asi hadzina kugumira ku) kudziviswa kwe:

• Tumor necrosis factor alpha (TNF-α) inokonzerwa ne lipopolysaccharide (LPS) mu macrophages. TNF-α inonzi cytokine inobatanidzwa mu systemic kuzvimba. Inobudiswa ne activated macrophages. Macrophages masero ekudzivirira anogona kumedza zvinhu zvekunze, tupukanana uye zvimwe zvinokuvadza kana kukuvadzwa zvinoriumba.
• Lipopolysaccharide-induced TNF-α uye interleukin (Il) -1α mRNA mazinga mumasero eglial, izvo zvinogona kutungamirira ku "kuderera neuronal cell apoptosis"
• Kudzivisa kugadzirwa kwemakemikari anokonzera kuzvimba
• Kudzivirira calcium kuti isayerera ichipinda mumaseru, nokudaro ichidzivirira:
◦ Kusunungurwa kwepro-inflammatory cytokines
◦ Intestinal mast masero anobudisa histamine uye serotonin 

Sekureva kwechinyorwa chino, quercetin inogonawo kudzikamisa mast masero, ine cytoprotective chiitiko pane gastrointestinal turakiti, uye "ine yakananga kudzora maitiro pane ekutanga mashandiro emasero emuviri", kuitira kuti igone "kudzika-kudzora kana kuvharidzira zvakasiyana-siyana." kuzvimba nzira uye mabasa," Inhibit nhamba yakakura yezvinangwa zvemamorekuru muiyo micromolar concentration renji".

Quercetin inogona kubatsira kune vanhu vazhinji

Tichifunga nezvehuwandu hwemabhenefiti equercetin, inogona kunge iri yekuwedzera inobatsira kune vanhu vazhinji, ingave yakaoma kana yenguva-refu matambudziko, inogona kuve nemhedzisiro. Ichi zvakare chekuwedzera ini ndinokurudzira kuti uchengete mune mushonga kabati. Zvinogona kuuya zvakanaka kana iwe uchinzwa kuti wave kuda "kuremerwa" nedambudziko rehutano (kungave chiri chikosoro kana furuu).

Kana iwe uchiwanzobatwa nedzihwa uye furuu, unogona kufunga kutora quercetin mwedzi mishoma mwaka wechando nefuruu isati yasvika kuti usimbise immune system yako. Mukufamba kwenguva, zvinoita sekunge zvinobatsira kune varwere vane metabolic syndrome, asi hupenzi hwakanyanya kuvimba chete nezvimwe zvinowedzera uye kutadza kugadzirisa matambudziko akadai sekudya uye kurovedza muviri panguva imwe chete.