Pakati pezvinyorwa zvitsva pamusoro peiyi antioxidant ine simba pane ongororo yakaburitswa muPhytotherapy Research munaKurume 2019, iyo yakaongorora zvinhu zvipfumbamwe nezvemhedzisiro yequercetin pa metabolic syndrome. Randomized controlled trial.

Metabolic syndrome inoreva matambudziko akawanda ehutano anowedzera njodzi yechirwere cheshuga cherudzi rwechipiri, chirwere chemwoyo, uye sitiroko, kusanganisira BP yakakwira, shuga yakakwira muropa, triglycerides yakakwira, uye mafuta akawanda muchiuno.

Kunyangwe zvidzidzo zvakakwana zvakawana kuti quercetin haina simba pakukura kweshuga muropa, kuramba insulin kana hemoglobin A1c levels, kumwe kuongorora kwemapoka kwakaratidza kuti quercetin yakawedzerwa muzvidzidzo zvakatora kanenge 500 mg pazuva kwemavhiki masere.” Shuga yeropa yakaderedzwa zvakanyanya.

Quercetin inobatsira kudzora kugadzirwa kwemajini

Sekureva kweongororo yakaburitswa muna 2016, quercetin inogona zvakare kumutsa nzira ye mitochondrial ye apoptosis (kufa kwemasero akakuvara kwakarongwa) nekubatana neDNA, zvichikonzera kudzokera shure kwebundu.

Ongororo dzakawana kuti quercetin inogona kukonzera chepfu mumasero eleukemia, uye mhedzisiro yacho ine chekuita nechiyero. Mhedzisiro shoma yechepfu mumasero yakawanikwawo mumasero ekenza yemazamu. Kazhinji, quercetin inogona kuwedzera hupenyu hwembeva dzekenza nekashanu kana tichienzanisa neboka revanoongorora vasina kurapwa.

Vanyori vanoti mhedzisiro iyi inokonzerwa nekudyidzana kwakananga pakati pequercetin neDNA uye kushanda kwayo munzira ye mitochondrial ye apoptosis, uye vanoti kushandiswa kwequercetin semushonga unobatsira pakurapa kenza kwakakodzera kuongororwa zvakanyanya.

Ongororo ichangobva kuburitswa mujenari reMolecules yakasimbisawo mhedzisiro ye epigenetic yequercetin uye kugona kwayo ku:

Kudyidzana nenzira dzekutumira masaini emasero
Gadzirisa kuratidzwa kwemajini
Kuchinja mashandiro ezvinhu zvinonyora zvinyorwa
Inodzora microribonucleic acid (microRNA)

Microribonucleic acid yaimboonekwa seDNA "isina basa". Ongororo dzakawana kuti DNA "isina basa" haina basa zvachose. Chaizvoizvo imorekuru diki ye ribonucleic acid, iyo inoita basa rakakosha mukudzora majini anogadzira mapuroteni evanhu.

Microribonucleic acid inogona kushandiswa se "switch" yemajini aya. Zvichienderana nezvinobuda mu microribonucleic acid, jini rinogona kunyora chero zvigadzirwa zveprotein zvinopfuura 200. Kugona kweQuercetin kugadzirisa ma microRNA kunogonawo kutsanangura mhedzisiro yayo ye cytotoxic uye nei ichiita seyakawedzera kupona kwekenza (kunyanya kumakonzo).

Quercetin chinhu chine simba chinorwisa mavhairasi

Sezvambotaurwa pamusoro apa, tsvakiridzo yakaitwa pamusoro pequercetin inotarisa kugona kwayo kurwisa mavhairasi, izvo zvinonyanya kukonzerwa nenzira nhatu dzekuita:

Dzima kugona kwemavhairasi kutapurira masero
Dzivisai kudzokororwa kwemasero ane utachiona
Kuderedza kuramba kwemasero ane utachiona kumishonga inorwisa mavhairasi

Semuenzaniso, ongororo yakatsigirwa nemari neUS Department of Defense yakaburitswa muna 2007 yakawana kuti mushure mekusangana nekushushikana kwakanyanya mumuviri, quercetin inogona kuderedza njodzi yako yekubatwa nehutachiona uye kuvandudza mashandiro epfungwa dzako, zvikasadaro inogona kukanganisa mashandiro emuviri wako, zvichiita kuti uve nyore kubatwa nezvirwere.

Muchidzidzo ichi, vanotasva mabhasikoro vakagamuchira 1000 mg yequercetin pazuva, pamwe chete nevhitamini C (inowedzera huwandu hwequercetin muplasma) uye niacin (inokurudzira kunyudzwa kweropa) kwemavhiki mashanu akatevedzana. Zvakawanikwa zvakaratidza kuti zvichienzaniswa neisina kurapwa. Kune chero munhu anotasva mabhasikoro akapihwa mushonga, avo vakatora quercetin vaiva nemukana wakaderera wekubatwa nechirwere chehutachiona mushure mekutasva bhasikoro kwemaawa matatu pazuva kwemazuva matatu akatevedzana. 45% yevanhu vari muboka re placebo vairwara, nepo 5% chete yevanhu vari muboka rekurapa vairwara.

Sangano reUS Defense Advanced Research Projects Agency (DARPA) rakatsigira imwe ongororo, iyo yakaburitswa muna 2008, uye rakadzidza nezvekushandiswa kwehutachiona hweH1N1 hunokonzera hutachiona hwakanyanya kurwisa mhuka dzakarapwa nequercetin. Mhedzisiro yacho ichiri imwe chete, kurwara nekufa kweboka rekurapa kwaive kwakaderera zvakanyanya pane kweboka re placebo. Zvimwe zvidzidzo zvakasimbisawo kushanda kwequercetin pakurwisa mavhairasi akasiyana-siyana, anosanganisira:

Ongororo yakaitwa muna 1985 yakawana kuti quercetin inogona kudzivirira hutachiona uye kudzokororwa kwehutachiona hweherpes simplex rudzi 1, poliovirus rudzi 1, parainfluenza virus rudzi 3, uye respiratory syncytial virus.

Chidzidzo chemhuka muna 2010 chakawana kuti quercetin inogona kudzivirira mavhairasi ese efuruwenza A neB. Kunewo zvinhu zviviri zvikuru zvakawanikwa. Chekutanga, mavhairasi aya haakwanise kuramba quercetin; chechipiri, kana akashandiswa pamwe chete nemishonga inorwisa mavhairasi (amantadine kana oseltamivir), mhedzisiro yawo inowedzera zvakanyanya - uye kukura kwekuramba hutachiona kunodzivirirwa.

Chidzidzo chemhuka muna 2004 chakabvumidza rudzi rwehutachiona hweH3N2, chichiongorora mhedzisiro yequercetin pafuruwenza. Munyori akataura kuti:

"Panguva yehutachiona hwefuruwenza, kushushikana kwe oxidative kunoitika. Nekuti quercetin inogona kudzorera huwandu hwe antioxidants akawanda, vamwe vanhu vanofunga kuti ingave mushonga unoshanda unogona kudzivirira mapapu kubva pakuburitswa panguva yehutachiona hwefuruwenza. Mhedzisiro inokuvadza ye oxygen free radicals."

Imwe ongororo ya2016 yakawana kuti quercetin inogona kudzora kugadzirwa kweprotein uye ine simba rekudzivirira pahutachiona hweH1N1 influenza. Kunyanya, kudzora kupisa kweprotein, fibronectin 1 uye protein inhibitory kunobatsira kuderedza kupararira kwehutachiona.

Chidzidzo chechitatu chakaburitswa muna 2016 chakawana kuti quercetin inogona kudzivirira mhando dzakasiyana dzefuruwenza, kusanganisira H1N1, H3N2, uye H5N1. Munyori weongororo iyi anotenda kuti, "Chidzidzo ichi chinoratidza kuti quercetin inoratidza kushanda kwekudzivirira pakutanga kwehutachiona hwefuruwenza, izvo zvinopa hurongwa hwekurapa hunoshanda mune ramangwana kuburikidza nekugadzira mishonga yechisikigo inoshanda, yakachengeteka, uye isingadhuri yekurapa nekudzivirira hutachiona hwe [Influenza A virus]."

Muna 2014, vaongorori vakataura kuti quercetin "inoita seyakanaka pakurapa dzihwa rinokonzerwa nema rhinoviruses" uye vakawedzera kuti, "Tsvagiridzo yakasimbisa kuti quercetin inogona kuderedza kupinda mukati uye kudzokororwa kwemavhairasi mu vitro. Muviri unogona kuderedza huwandu hwehutachiona, pneumonia uye kupindura kwakanyanya kwemhepo."

Quercetin inogonawo kuderedza kukuvara kwe oxidative, nokudaro ichideredza njodzi yehutachiona hwechipiri, hunova ndihwo hunonyanya kukonzera kufa kunokonzerwa nefuruwenza. Chinokosha ndechekuti quercetin inowedzera kugadzirwa kwemitochondrial mutsandanyama dzemapfupa, zvichiratidza kuti chimwe chezviito zvayo zvekurwisa mavhairasi chinokonzerwa nekuwedzera kwechiratidzo che mitochondrial antiviral.

Ongororo yemhuka muna 2016 yakawana kuti quercetin inogona kudzivirira hutachiona hwedengue uye hutachiona hwehepatitis mumakonzo. Zvimwe zvidzidzo zvakasimbisawo kuti quercetin ine simba rekudzivirira hutachiona hwehepatitis B neC.

Munguva pfupi yapfuura, chidzidzo chakaburitswa mujenari reMicrobial Pathogenesis munaKurume 2020 chakawana kuti quercetin inogona kupa dziviriro yakakwana kubva kuhutachiona hweStreptococcus pneumoniae zvese mu vitro uye mu vivo. Chepfu (PLY) inoburitswa nepneumococcus kudzivirira kubuda kwehutachiona hweStreptococcus pneumoniae. Mumushumo wekuti "Microbial Pathogenesis", munyori akataura kuti:

"Mhedzisiro yacho inoratidza kuti quercetin inoderedza zvakanyanya basa rehemolytic uye cytotoxicity inokonzerwa nePLY nekudzivisa kuumbwa kweoligomers."
Pamusoro pezvo, kurapwa nequercetin kunogonawo kuderedza kukuvara kwemasero kunokonzerwa nePLY, kuwedzera huwandu hwekupona kwemakonzo ane Streptococcus pneumoniae inouraya, kuderedza kukuvara kwemapapu, uye kudzivirira ma cytokines (IL-1β neTNF) mukuburitswa kwemvura ye bronchoalveolar lavage. -α).
Tichifunga nezvekukosha kwezviitiko izvi mukukura kwechirwere cheStreptococcus pneumoniae chisingarapiki, zvatakawana zvinoratidza kuti quercetin inogona kuva mushonga mutsva unoshandiswa pakurapa hutachiona hwepneumococcal.
Quercetin inorwisa kuzvimba uye inowedzera mashandiro emuviri

Kuwedzera pakushanda kwemishonga inorwisa mavhairasi, quercetin inogonawo kuwedzera dziviriro yemuviri uye kurwisa kuzvimba. Chidzidzo chakaitwa muna 2016 chakaburitswa mujenari reNutrients chakaratidza kuti nzira dzekushanda dzinosanganisira (asi hadzigumiri pa) kudzivirira:

• Tumor necrosis factor alpha (TNF-α) inokonzerwa ne lipopolysaccharide (LPS) muma macrophages. TNF-α i cytokine inobatanidzwa mukuzvimba kwemuviri. Inoburitswa nema macrophages anoshandiswa. Macrophages masero ekudzivirira muviri anogona kumedza zvinhu zvekunze, tupukanana nezvimwe zvinhu zvinokuvadza kana zvakakuvara.
• Mazinga eTNF-α anokonzerwa neLipopolysaccharide uye interleukin (Il)-1α mRNA mumasero eglial, izvo zvinogona kukonzera "kudzikira kweapoptosis yemasero eneuronal"
• Kudzivirira kugadzirwa kwema enzyme anokonzera kuzvimba
• Dzivirira calcium kuti isapinde mumasero, nokudaro ichidzivisa:
◦ Kuburitswa kwema cytokines anokonzera kuzvimba
◦ Masero emudumbu anoburitsa histamine neserotonin 

Sekureva kwechinyorwa chino, quercetin inogonawo kudzikamisa masero emuviri, ine basa rekudzivirira masero mudumbu, uye "ine simba rekutonga zvakananga pamabasa ekutanga emasero ekudzivirira muviri", kuitira kuti igone "kuderedza kana kudzivirira nzira dzakasiyana-siyana dzekuzvimba," Kudzivirira huwandu hwakawanda hwezvinangwa zvemamorekuru muhuwandu hwe micromolar concentration".

Quercetin inogona kubatsira vanhu vazhinji

Tichifunga nezvemabhenefiti akasiyana-siyana equercetin, inogona kuva mushonga unobatsira vanhu vazhinji, ingave iri dambudziko guru kana renguva refu, inogona kuva nemigumisiro yakati. Uyu mushonga unowedzerawo zvandinokurudzira kuti ugare nawo mukamuri remishonga. Unogona kubatsira kana uchinzwa kuti wava kuda "kukundwa" nedambudziko rehutano (ingave iri dzihwa kana furuu).

Kana uchiwanzobatwa nedzihwa nefuruu, ungafunga nezvekutora quercetin mwedzi mishomanana mwaka wedzihwa nefuruu usati wasvika kuti usimbise dziviriro yemuviri wako. Nekufamba kwenguva, zvinoita sezvinobatsira zvikuru kune varwere vane metabolic syndrome, asi upenzi hwakanyanya kuvimba chete nezvimwe zvinovaka muviri wotadza kugadzirisa matambudziko makuru akadai sekudya uye kurovedza muviri panguva imwe chete.