Muchidzidzo chitsva, vaongorori vakawana kuti mushonga mutsva wakavakirwa pachikamu chembeu yemazambiringa inotorwa unogona kubudirira kuwedzera hupenyu uye hutano hwembeva.
Chidzidzo ichi, chakaburitswa mujenari Nature Metabolism, chinoisa hwaro hwezvimwe zvidzidzo zvekiriniki kuona kana mhedzisiro iyi inogona kudzokororwa muvanhu.
Kuchembera ndicho chinhu chikuru chengozi yezvirwere zvakawanda zvisingaperi. Masayendisiti anotenda kuti izvi zvakakonzerwa nekuchembera kwemaserura. Izvi zvinoitika kana maseru asingachakwanise kuita mabasa awo ebhayoloji mumuviri.
Mumakore achangopfuura, vaongorori vakawana kirasi yemishonga inonzi senolytics. Mishonga iyi inogona kuparadza maseru maseru murabhoritari uye mhando dzemhuka, zvichigona kuderedza kuitika kwezvirwere zvisingaperi zvinomuka sezvatinokura nekurarama kwenguva refu.
Muchidzidzo ichi, masayendisiti akawana senolytic nyowani yakatorwa kubva muchikamu chemhodzi yemazambiringa inonzi proanthocyanidin C1 (PCC1).
Zvichienderana nedatha yapfuura, PCC1 inotarisirwa kuvharidzira kuita kwesesescent maseru panzvimbo yakaderera uye nekusarudza kuparadza maseru maseru pamatunhu akakwirira.
Mukuyedza kwekutanga, vakafumura mbeva kune sublethal doses yemwaranzi yekukurudzira cellular senescence. Rimwe boka rembeva rakazogamuchira PCC1, uye rimwe boka rakagamuchira motokari yakatakura PCC1.
Vatsvakurudzi vakaona kuti mushure mekunge mbeva dzave dzichiratidzwa neradiation, dzakagadzira hunhu husina kujairika, kusanganisira huwandu hukuru hwebvudzi.
Kurapwa kwemakonzo nePCC1 kwakachinja zvakanyanya maitiro aya. Mbeva dzakapihwa PCC1 zvakare dzaive nemasero mashoma ane senescent uye biomarkers akabatana nesenescent maseru.
Pakupedzisira, mbeva dzakasvibiswa dzaive nekushanda kushoma uye simba remhasuru. Nekudaro, mamiriro acho akachinja mumakonzo akapihwa PCC1, uye vaive nehuwandu hwekupona.
Muchiyedzo chechipiri, vaongorori vakabaya mbeva dzekuchembera nePCC1 kana mota mavhiki maviri ega ega kwemwedzi mina.
Chikwata chakawana huwandu hukuru hwesesescent masero muitsvo, chiropa, mapapu uye prostates emakonzo ekare. Zvisinei, kurapwa nePCC1 kwakashandura mamiriro acho ezvinhu.
Mbeva dzakabatwa nePCC1 dzakaratidzawo kuvandudzwa kwesimba rekubata, kukurumidza kufamba, kutsungirira kwakarembera, treadmill kutsungirira, nhanho yezuva nezuva, uye kuenzanisa zvichienzaniswa nemakonzo akagamuchira motokari chete.
Mukuyedza kwechitatu, vaongorori vakatarisa mbeva dzekare kuti vaone kuti PCC1 yakakanganisa sei hupenyu hwavo.
Vakaona kuti mbeva dzaibatwa nePCC1 dzairarama avhareji ye9.4% kureba kupfuura mbeva dzaibatwa nemotokari.
Uyezve, pasinei nekugara kwenguva refu, PCC1-yakarapwa mbeva haina kuratidza chero zera-ane hukama hwepamusoro hunofananidzwa nemakonzo anobatwa nemotokari.
Vachipeta zvakawanikwa, munyori anofambirana naProfessor Sun Yu weShanghai Institute of Nutrition and Health kuChina nevamwe vatinoshanda navo vakati: “Isu tinopa humbowo hwemusimboti wekuti [PCC1] inokwanisa kunonoka zvakanyanya kusashanda zvakanaka kwezera kunyangwe ikatorwa.” gare gare muhupenyu, ine mukana mukuru wekudzikisa zvirwere zvine chekuita nezera uye kuvandudza mhedzisiro yehutano, nekudaro kuvhura nzira nyowani dzeramangwana mushonga wegeriatric kuvandudza hutano uye hupenyu hurefu. "
Dr James Brown, nhengo yeAston Center for Healthy Kuchembera muBirmingham, UK, akaudza Medical News Nhasi kuti zvakawanikwa zvinopa humwe humbowo hwekugona kubatsira kwemishonga inorwisa kuchembera. Dr. Brown vakanga vasina kubatanidzwa mukudzidza kwemazuva ano.
"Senolytics ikirasi nyowani yeanorwisa-kuchembera makomisheni ayo anowanzo kuwanikwa mune zvakasikwa. Ichi chidzidzo chinoratidza kuti PCC1, pamwe chete nemakomisheni akadai sequercetin uye fisetin, inokwanisa kuuraya nerusaruro maseru maseru ichibvumira masero madiki, ane hutano kuchengetedza kushanda kwakanaka. ”
"Chidzidzo ichi, sezvimwe zvidzidzo munharaunda ino, chakaongorora mhedzisiro yemakemikari aya mumakonzo uye zvimwe zvipenyu zvakaderera, saka basa rakawanda rinosara risati razivikanwa mhedzisiro yekurwisa kuchembera muvanhu."
"Senolytics zvechokwadi inobata chivimbiso chekuva mishonga inorwisa kukwegura mukubudirira," Dr. Brown akadaro.
Muzvinafundo Ilaria Bellantuono, purofesa wekuchembera musculoskeletal paYunivhesiti yeSheffield kuUK, akabvumirana mubvunzurudzo neMNT kuti mubvunzo wakakosha ndewekuti izvi zvakawanikwa zvinogona kudzokororwa muvanhu. Muzvinafundo Bellantuono haanawo kubatanidzwa muchidzidzo ichi.
"Chidzidzo ichi chinowedzera humbowo hwekuti kunanga maseru nemishonga inovauraya, inonzi 'senolytics,' inogona kuvandudza kushanda kwemuviri sezvatinochembera uye kuita kuti chemotherapy ishande mugomarara."
“Zvakakosha kuziva kuti data rese riri munzvimbo ino rinobva kumhando dzemhuka — mune iyi nyaya, mhando yemakonzo. Dambudziko chairo nderekuongorora kana mishonga iyi inoshanda zvakaenzana [muvanhu]. Hapana data iripo panguva ino. " , uye miedzo yekiriniki ichangotanga,” akadaro Purofesa Bellantuono.
Dr David Clancy, vekuFaculty yeBiomedicine uye Biological Sayenzi paLancaster University kuUK, vakaudza MNT kuti mazinga edosi anogona kuve dambudziko kana uchiisa zvawanikwa kuvanhu. Dr. Clancy havana kubatanidzwa muongororo ichangopfuura.
“Mishonga inopihwa mbeva kazhinji yakakura zvikuru kana ichienzaniswa neinobvumirwa nevanhu. Madosi akakodzera ePCC1 muvanhu anogona kukonzera chepfu. Zvidzidzo mumakonzo zvinogona kudzidzisa; chiropa chavo chinoita sechinogaya zvinodhaka sechiropa chomunhu kupfuura chiropa chembeva. ”
Dr Richard Siow, director wekutsvagisa kuchembera paKing's College London, akaudzawo MNT kuti tsvakiridzo yemhuka isiri yevanhu inogona kunge isingaite kutungamira kune zvakanaka kiriniki muvanhu. Dr. Siow akanga asinawo kubatanidzwa muchidzidzo.
“Kuwanikwa kwemakonzo, makonye nenhunzi handigare ndichienzanisa nevanhu, nekuti zviri pachena ndezvekuti tine maakaundi ekubhanga ivo vasina. Tine zvikwama, asi havana. Tine zvimwe zviro muhupenyu. Simbisa kuti mhuka Hatina: chikafu, kutaurirana, basa, Zoom mafoni. Ndine chokwadi chekuti makonzo anogona kusimbiswa nenzira dzakasiyana, asi kazhinji isu tinonyanya kunetseka nezvebhangi redu,” Dr. Xiao akadaro.
"Ehe, uku kuseka, asi kune mamiriro, zvese zvaunoverenga nezve mbeva hazvigone kuturikirwa kuvanhu. Dai wanga uri mbeva uye uchida kurarama kusvika makore mazana maviri - kana mbeva yakaenzana. Pamakore 200, zvingava zvakanaka, asi zvine musoro kuvanhu here? Ikoko nguva dzose ichenjedzo pandinotaura nezvekutsvakurudza nezvemhuka.”
"Parutivi rwakanaka, ichi chidzidzo chakasimba chinotipa humbowo hwakasimba hwekuti kunyangwe nzira zhinji dzandakanangana netsvakiridzo yangu dzakakosha kana tichifunga nezvehupenyu hwese."
"Kunyangwe iri mhando yemhuka kana yemhando yemunhu, panogona kunge paine nzira dzakananga dzemamorekuru dzatinofanira kutarisa mumamiriro ezvinhu ekuedzwa kwekiriniki kwevanhu nemakomponi akaita sembeu yemazambiringa proanthocyanidins," Dr. Siow akadaro.
Dr. Xiao vakati imwe nzira yekugadzira mbeu yemazambiringa semushonga wezvekudya.
“Kuva nemuenzaniso wakanaka wemhuka une migumisiro yakanaka [uye kudhindwa mujenari rine ruzivo rwakanyanya] kunowedzera huremu kubudiriro nekudyara mutsvakurudzo yekiriniki yevanhu, ingave kubva kuhurumende, miedzo yekiriniki kana kuti kuburikidza nevanoisa mari nemaindasitiri. Torai bhodhi rinopikisa uye isa mhodzi dzemazambiringa mumapiritsi sechikafu chekuwedzera maererano nezvinyorwa izvi. "
“Mushonga wandiri kutora unogona kunge usina kuongororwa nekiriniki, asi data yemhuka inoratidza kuti inowedzera huremu - izvo zvinoita kuti vatengi vafunge kuti mune chimwe chinhu mairi. Ndiwo mamwe maonero anoita vanhu nezvechikafu.” additives.” neimwe nzira, izvi zvinobatsira pakunzwisisa hupenyu hurefu,” Dr. Xiao vakadaro.
Dr. Xiao akasimbisa kuti mararamiro emunhu anokoshawo, kwete chete kuti anorarama kwenguva yakareba sei.
"Kana isu tine hanya nezve tarisiro yehupenyu uye, zvakanyanya kukosha, tarisiro yehupenyu, isu tinofanirwa kutsanangura kuti tarisiro yehupenyu inorevei. Zvakanaka kana tikararama kusvika 150, asi hazvina kunaka kana tikapedza makore makumi mashanu ekupedzisira tiri pamubhedha. "
“Saka panzvimbo pokurarama kwenguva refu, zvichida nguva iri nani ingava utano noupenyu hurefu: ungave uri kuwedzera makore kuupenyu hwako, asi uri kuwedzera makore kuupenyu hwako here? Kana kuti makore aya haana maturo? Uye hutano hwepfungwa: unogona kurarama kusvika makore zana nemakumi matatu. chembere, asi kana usingakwanisi kunakidzwa nemakore aya, zvine basa here?”
"Zvakakosha kuti titarise maonero akafara ehutano hwepfungwa nekugara zvakanaka, kushaya simba, matambudziko ekufamba, mazera atinoita munharaunda - kune mishonga yakakwana here? Kana kuti tinoda mamwe kuchengetedzwa kwevanhu? Kana isu tine rutsigiro rwekurarama kune 90, 100 kana 110? Hurumende ine mutemo here?”
“Kana mishonga iyi iri kutibatsira, isu tave nemakore anopfuura 100, chii chatingaite kusimudzira hupenyu hwedu pane kungotora mishonga yakawanda? Muno mune mhodzi dzemazambiringa, matamba nezvimwe,” vakadaro Dr. Xiao. .
Muzvinafundo Bellantuono vakati mhedzisiro yechidzidzo ichi ichanyanya kukosha kumiyedzo yekiriniki inosanganisira varwere vegomarara vanowana chemotherapy.
"Dambudziko rinowanzoitika nevanolytics kuona kuti ndiani achabatsirika kubva kwavari uye nzira yekuyera kubatsirwa mumiyedzo yekiriniki."
"Uyezve, nekuti mishonga yakawanda inoshanda zvakanyanya pakudzivirira chirwere pane kuchirapa kana yangoonekwa, miedzo yekiriniki inogona kutora makore zvichienderana nemamiriro ezvinhu uye inogona kudhura zvakanyanya."
"Zvisinei, munyaya iyi, [vatsvakurudzi] vakaona boka revarwere vaizobatsirwa nazvo: varwere vekenza vanowana chemotherapy. Uyezve, zvinozivikanwa apo kuumbwa kwemasero emasero kunokonzerwa (kureva nechemotherapy) uye apo "Uyu muenzaniso wakanaka wehumbowo-ye-pfungwa yekudzidza inogona kuitwa kuedza kushanda kwesenolytics muvarwere," akadaro Purofesa. Bellantuono. ”
Masayendisiti akabudirira uye zvakachengeteka kudzoreredza zviratidzo zvekuchembera mumakonzo nekugadzirazve mamwe masero avo.
Chidzidzo cheBaylor College yeMishonga chakawana kuti ma supplements anononoka kana kugadzirisa zvinhu zvekuchembera kwechisikigo mumakonzo, zvingangorebesa…
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