Muchidzidzo chitsva, vaongorori vakawana kuti mushonga mutsva wakavakirwa pachikamu chembeu yemazambiringa unogona kuwedzera hupenyu hwembeva neutano hwadzo.
Chidzidzo ichi, chakaburitswa mumagazini inonzi Nature Metabolism, chinoisa hwaro hwezvidzidzo zvekiriniki kuti zvionekwe kana mhedzisiro iyi ichigona kudzokororwa muvanhu.
Kukwegura chinhu chikuru chinokonzera zvirwere zvakawanda zvisingaperi. Masayendisiti anotenda kuti izvi zvinokonzerwa nekukwegura kwemasero. Izvi zvinoitika kana masero asingachakwanisi kuita mabasa awo emuviri mumuviri.
Mumakore achangopfuura, vaongorori vakawana mhando yemishonga inonzi senolytics. Mishonga iyi inogona kuparadza masero emasero ari murabhoritari nemhuka, zvichigona kuderedza kuwanda kwezvirwere zvisingaperi zvinomuka patinokura uye tichirarama kwenguva refu.
Muchidzidzo ichi, masayendisiti akawana mushonga mutsva unobva muchikamu chembeu yemazambiringa chinonzi proanthocyanidin C1 (PCC1).
Zvichibva pane data rapfuura, PCC1 inotarisirwa kudzivirira kushanda kwemasero achangoberekwa pahuwandu hwakaderera uye kuparadza masero achangoberekwa pahuwandu hwakanyanya.
Mukuedza kwekutanga, vakaisa mbeva mumwaranzi isingauraye zvakanyanya kuti iite kuti masero achembera. Rimwe boka rembeva rakazogamuchira PCC1, uye rimwe boka rakawana mota yakatakura PCC1.
Vaongorori vakaona kuti mushure mekunge mbeva dzabatwa nemwaranzi, dzakatanga kuva neunhu husina kujairika, kusanganisira bvudzi rakawanda regrey.
Kurapa mbeva nePCC1 kwakachinja zvikuru hunhu uhwu. Mbeva dzakapihwa PCC1 dzaivewo nemasero mashoma ekuberekwa uye zviratidzo zvebiomarker zvine chekuita nemasero ekuberekwa.
Pakupedzisira, mbeva dzakapiswa nemwaranzi dzakanga dzisina simba rakawanda uye tsandanyama dzakasimba. Zvisinei, mamiriro ezvinhu akachinja mumakonzo akapihwa PCC1, uye aiva nehuwandu hwakakura hwekupona.
Mukuyedza kwechipiri, vaongorori vakabaya mbeva dzinokura nePCC1 kana kuti jekiseni rePCC1 mavhiki maviri ega ega kwemwedzi mina.
Chikwata ichi chakawana huwandu hwakawanda hwemasero ekukura muitsvo, chiropa, mapapu uye prostate dzembeva dzekare. Zvisinei, kurapwa nePCC1 kwakachinja mamiriro acho ezvinhu.
Mbeva dzakarapwa nePCC1 dzakaratidzawo kuvandudzwa kwesimba rekubata, kumhanya kwakanyanya kwekufamba, kutsungirira kurembera, kutsungirira kwetreadmill, nhanho yekushanda kwezuva nezuva, uye kuenzana zvichienzaniswa nembeva dzaigamuchira mota chete.
Mukuedza kwechitatu, vaongorori vakatarisa mbeva dzekare kuti vaone kuti PCC1 yakakanganisa sei hupenyu hwadzo.
Vakaona kuti mbeva dzakarapwa nePCC1 dzairarama avhareji ye9.4% kwenguva yakareba kupfuura mbeva dzakarapwa nemotokari.
Uyezve, pasinei nekurarama kwenguva yakareba, mbeva dzakarapwa nePCC1 hadzina kuratidza kurwara kwakanyanya nekuda kwezera kana tichienzanisa nembeva dzakarapwa nemotokari.
Achipfupisa zvakawanikwa, munyori anoenderana naye Purofesa Sun Yu wekuShanghai Institute of Nutrition and Health muChina nevamwe vake vakati: “Pano tinopa humbowo hwekuti [PCC1] ine simba rekunonotsa zvakanyanya kusashanda zvakanaka kwemishonga ine chekuita nekukwegura kunyangwe ikatorwa.” Pave paya muhupenyu, ine mukana mukuru wekuderedza zvirwere zvine chekuita nekukwegura uye kuvandudza hutano, nokudaro ichivhura nzira itsva dzekurapa vakwegura mune ramangwana kuti ivandudze hutano nekugara kwenguva refu.”
Dr James Brown, nhengo yeAston Center for Healthy Aging muBirmingham, UK, vakaudza Medical News Today kuti zvakawanikwa izvi zvinopa humwe humbowo hwekubatsira kunogona kuwanikwa nemishonga inoderedza kukwegura. Dr. Brown haana kubatanidzwa muongororo yakaitwa munguva pfupi yapfuura.
"Senolytics iboka idzva remishonga inodzivirira kukwegura inowanikwa muzvisikwa. Chidzidzo ichi chinoratidza kuti PCC1, pamwe chete nemishonga yakaita sequercetin nefisetin, inokwanisa kuuraya masero achangotanga kukura uku ichibvumira masero madiki ane hutano kuti arambe achirarama zvakanaka."
"Chidzidzo ichi, sezvimwe zvidzidzo zviri munharaunda iyi, chakaongorora migumisiro yemakemikari aya mumakonzo nezvimwe zvipenyu zvepasi, saka basa rakawanda richiripo risati raonekwa kuti migumisiro yemakemikari aya muvanhu inorwisa kukwegura."
"Senolytics zvechokwadi ine vimbiso yekuti ndiyo mishonga inotungamira mukugadzirwa kwemishonga inoderedza kukwegura," akadaro Dr. Brown.
Purofesa Ilaria Bellantuono, purofesa wezvekukwegura kwetsandanyama nemapfupa paYunivhesiti yeSheffield kuUK, vakabvumirana mubvunzurudzo neMNT kuti mubvunzo mukuru ndewekuti zvakawanikwa izvi zvinogona here kudzokororwa muvanhu. Purofesa Bellantuono haanawo kubatanidzwa muchidzidzo ichi.
"Chidzidzo ichi chinowedzera humbowo hwekuti kushandisa mishonga inouraya masero achangoberekwa, inonzi 'senolytics,' kunogona kuvandudza mashandiro emuviri sezvatinokura uye kuita kuti mishonga yechemotherapy ishande zvakanyanya mukurapa kenza."
"Zvakakosha kuziva kuti data rese riri munharaunda iyi rinobva kumhando dzemhuka—munyaya iyi, mhando dzembeva. Dambudziko guru nderekuyedza kana mishonga iyi inoshanda zvakaenzana [muvanhu]. Hapana data riripo panguva ino." , uye miedzo yekiriniki iri kutanga," akadaro Purofesa Bellantuono.
Dr David Clancy, vekuFaculty of Biomedicine and Biological Sciences paLancaster University muUK, vakaudza MNT kuti huwandu hwemushonga hunogona kuva dambudziko kana mhedzisiro yacho ikashandisa kuvanhu. Dr. Clancy haana kubatanidzwa muongororo yakaitwa nguva pfupi yadarika.
"Mipimo inopiwa kumakonzo inowanzo kuve yakakura zvikuru kana tichienzanisa neiyo vanhu vanogona kushivirira. Mipimo yakakodzera yePCC1 muvanhu inogona kukonzera chepfu. Zvidzidzo mumakonzo zvinogona kuva neruzivo; chiropa chavo chinoita sechinogadzirisa mishonga zvakanyanya sechiropa chemunhu kupfuura chiropa chembeva."
Dr Richard Siow, mukuru weongororo yekukwegura paKing's College London, vakaudzawo MNT kuti ongororo yemhuka dzisiri dzevanhu inogona kunge isiriyo inotungamira kune mhedzisiro yakanaka muvanhu. Dr. Siow haanawo kubatanidzwa muchidzidzo ichi.
"Handiwanzo enzanisa kuwanikwa kwemakonzo, honye nenhunzi nevanhu, nekuti chokwadi chiri nyore ndechekuti tine maakaundi ebhangi asi haana. Tine mawallet, asi haana. Tine zvimwe zvinhu muhupenyu. Simbisa kuti mhuka Hatina: chikafu, kutaurirana, basa, kufona kweZoom. Ndine chokwadi chekuti makonzo anogona kushushikana nenzira dzakasiyana, asi kazhinji tinonyanya kunetseka nezvemari yedu yebhangi," akadaro Dr. Xiao.
"Ehe, iyi inyaya yekuseka, asi kana tichitarisa mamiriro acho ezvinhu, zvese zvaunoverenga nezvembeva hazvigone kushandurirwa kuvanhu. Dai waiva mbeva uye uchida kurarama kusvika wava nemakore mazana maviri - kana kuti mbeva yakafanana nayo. Pamakore mazana maviri, izvozvo zvaizova zvakanaka, asi zvine musoro here kuvanhu? Izvozvo zvinogara zviri chenjedzo pandinotaura nezvekutsvagurudza mhuka."
"Kune rumwe rutivi, iyi iongororo yakasimba inotipa humbowo hwakasimba hwekuti kunyange nzira dzakawanda dzandakanyatsotarisa patsvagurudzo yangu dzakakosha kana tichifunga nezvehupenyu hwese."
"Ingava muenzaniso wemhuka kana muenzaniso wemunhu, pangave paine nzira dzakati wandei dzemamorekuru dzatinofanira kutarisa mumamiriro ekuedzwa kwevanhu nemishonga yakaita seproanthocyanidins yembeu yemazambiringa," akadaro Dr. Siow.
Dr. Xiao vakati imwe nzira inogona kushandiswa kugadzira mbeu yemazambiringa sechikafu chinovaka muviri.
"Kuva nemuenzaniso wakanaka wemhuka une mhedzisiro yakanaka [uye kuburitswa mujenari rine simba guru] kunowedzera kukosha mukuvandudzwa nekudyara mari muongororo yekiriniki yevanhu, kungave kubva kuhurumende, miedzo yekiriniki kana kuburikidza nevanoisa mari nemaindasitiri. Tora bhodhi iri rezvipingamupinyi woisa mbeu dzemazambiringa mumapiritsi sechikafu chinowedzera kubva muzvinyorwa izvi."
"Chimwe chinhu chandinenge ndichitora chingave chisina kuongororwa mukiriniki, asi ruzivo rwemhuka runoratidza kuti chinowedzera huremu - izvo zvinoita kuti vatengi vatende kuti pane chimwe chinhu chiri machiri. Ichi chikamu chemaonero anoita vanhu nezvechikafu." zvimwe zvinhu zvinowedzerwa. "nedzimwe nzira, izvi zvinobatsira pakunzwisisa hupenyu hurefu," akadaro Dr. Xiao.
Dr. Xiao vakasimbisa kuti hupenyu hwemunhu hwakakoshawo, kwete chete kuti anorarama kwenguva yakareba sei.
"Kana tichida nezvenguva yekurarama uye, chinonyanya kukosha, nguva yekurarama, tinofanira kutsanangura zvinorehwa nenguva yekurarama. Hazvina kuipa kana tikararama kusvika pamakore 150, asi hazvina kunaka kana tikapedza makore makumi mashanu apfuura tiri pamubhedha."
"Saka pachinzvimbo chekurarama kwenguva refu, pamwe izwi riri nani ringave hutano nekurarama kwenguva refu: ungangove uchiwedzera makore muhupenyu hwako, asi uri kuwedzera makore muhupenyu hwako here? Kana kuti makore aya haana zvaanoreva here? Uye hutano hwepfungwa: unogona kurarama kusvika wava nemakore 130 ekuberekwa. asi kana usingakwanise kunakidzwa nemakore aya, zvakakodzera here?"
"Zvakakosha kuti titarise maonero akafara ehutano hwepfungwa nekugara zvakanaka, kushaya simba, matambudziko ekufamba-famba, kuti tinokwegura sei munharaunda - kune mishonga yakakwana here? Kana kuti tinoda rubatsiro rwakawanda rwevanhu? Kana tiine rutsigiro rwekurarama kusvika pamakore 90, 100 kana 110? Hurumende ine mutemo here?"
"Kana mishonga iyi iri kutibatsira, uye isu tava nemakore anopfuura zana, chii chatingaita kuti tivandudze hupenyu hwedu pane kungotora mishonga yakawanda? Pano une mhodzi dzemazambiringa, mapomegraneti, nezvimwewo," akadaro Dr. Xiao.
Purofesa Bellantuono vakati mhedzisiro yechidzidzo ichi ichave yakakosha zvikuru pakuyedzwa kwekiriniki kunosanganisira varwere vegomarara vachirapwa chemotherapy.
"Dambudziko rinowanzoitika nesenolytics nderekuona kuti ndiani achabatsirwa naro uye kuti ungayera sei kubatsira kwaro mumiedzo yekiriniki."
"Uyezve, nekuda kwekuti mishonga yakawanda inoshanda zvakanyanya pakudzivirira chirwere pane kuchirapa kana changoonekwa, kuyedzwa kwekiriniki kunogona kutora makore zvichienderana nemamiriro ezvinhu uye kunogona kudhura zvakanyanya."
"Zvisinei, munyaya iyi chaiyo, [vaongorori] vakaona boka revarwere vaizobatsirwa nazvo: varwere vegomarara vanowana chemotherapy. Uyezve, zvinozivikanwa kuti kuumbwa kwemasero e senescent kunokonzerwa rini (kureva ne chemotherapy) uye kuti "Uyu muenzaniso wakanaka wechidzidzo cheuchapupu hwepfungwa chinogona kuitwa kuyedza kushanda kwesenolytics muvarwere," akadaro Purofesa Bellantuono.
Masayendisiti akabudirira uye zvakachengeteka kubvisa zviratidzo zvekukwegura mumakonzo nekugadzira mamwe masero avo nemajini.
Chidzidzo cheBaylor College of Medicine chakawana kuti zvinovaka muviri zvinoderedza kana kugadzirisa kukwegura kwechisikigo mumakonzo, zvichigona kuwedzera nguva…
Ongororo itsva yakaitwa mumakonzo nemasero evanhu yakawana kuti mishonga yemichero inogona kuderedza BP. Ongororo iyi inoratidzawo nzira yekuzadzisa chinangwa ichi.
Masayendisiti akaisa ropa rembeva dzekare mumakonzo madiki kuti vaone kana uye kuti vaideredza sei migumisiro yacho.
Kudya kunorwisa kukwegura kuri kuramba kuchifarirwa. Muchinyorwa chino tinokurukura zvakawanikwa paongororo yehumbowo yakaitwa munguva pfupi yapfuura uye tinobvunza kana paine chimwe che…