Kuiswa kweCitrus Aurantium

Citrus Aurantium, chirimwa chemhuri yerutaceae, chinoparadzirwa zvakanyanya kuChina.Citrus aurantium ndiro zita rechinyakare reChinese re lime.Muchivanhu cheChinese mushonga, citrus aurantium igwenzi rechivanhu rinonyanya kushandiswa kuwedzera chido uye kutonga qi (simba).MuItaly, citrus aurantium yanga iriwo mushonga wechivanhu kubva muzana ramakore rechi 16, yaishandiswa kurapa fivha yakaita semarariya uye semushonga unorwisa utachiona.Zvidzidzo zvenguva ichangopfuura zvakaratidza kuti citrus aurantium inogona kutsiva ephedra pakurapa kufutisa pasina zvakaipa zvemwoyo netsinga.

Iyo inoshanda ye citrus aurantium ndeye hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Active ingredient

Hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Pfuma yenyama

Crystallization, melting point 184-1850C, carbonate crystallization 151-152, inonyungudika nyore mumvura.Bitartrate, melting point 188-189, inonyungudika mumvura, yakaoma kunyungudika mu ethanol, inenge isinganyungudike muchloroform, ether.Hydrochloride, crystal isina ruvara (ethanol-ethyl ether), inonyunguduka 166-167.Iyo racemization iri nyore kuitika mukuparadzaniswa kwechromatography yeasidhi yakasimba uye base ion exchange resins.

Pharmacological effect
1. Mhedzisiro pachibereko: Fructus Aurantii uye Fructus Aurantii Fructus Decoction kubva munzvimbo nhatu dzakasiyana dzekubudisa (Sichuan, Jiangxi, uye Hunan) yakaratidza inhibitory effect pachibereko in vitro yemakonzo (ane pamuviri uye asina pamuviri);Chibereko chetsuro chaifadza zvose mu vivo uye in vitro (ane pamuviri uye asina pamuviri).Tsuro uterine fistula yakaratidzawo kuita kuti uterine contractions dzive dzakasimba, tension yakawedzera, uye kunyange tetanic contraction.Fructus Aurantii tincture uye Fructus Aurantii fluid inotorwa inogonawo kufadza chibereko chetsuro (in vivo uye in vitro).Mouse uterus (in vitro) yakavharwa.Chinhu chealkaloid chakaparadzaniswa kubva kuFructus Aurantii neLycium orange zvakare chaive neimwe contractile effect pa tsuro uterus in vitro, kunyanya pamhasuru yechibereko inonakirwa nepituitrin.Chikamu chealkaloid chakabviswa chaive nekuzorodza chibereko chetsuro in vitro, uye kuzorora kwechibereko kwainyanya kuoneka mushure mekunakidzwa kwe hypophysial.Cirantin, yakaparadzaniswa kubva kuFructus Aurantii Fructus Peel, inhibits hyaluronate basa rakapoteredza ovary, iyo inogona kunge yakabatana nekudzivirira kwayo kwekudzivirira (kudzivirira kubereka).

2. Mhedzisiro paura: Fructus Aurantii naFructus Aurantii kubva kunzvimbo nhatu dzakasiyana dzakadzivisa ura mumakonzo netsuro;Mazhinji emachubhu emukati mutsuro akavharwa, asi mashoma aive asina shanduko.Fructus Aurantii uye yakabudiswa mvura yakavharira machubhu emukati emakonzo (in vitro) uye tsuro (in vitro).High concentration (1: 1000) yakadzivisa ura hudiki hwetsuro dziri dzoga uye guinea nguruve uye yakadzivisa migumisiro yeacetylcholine uye histamine.Kudzika kwakadzika (1: 10 000), mushure mechinguva chiduku chekudzivisa, inogona kuratidza chiitiko chekunakidza, amplitude yakawedzera, uye frequency inowedzera.Mune imbwa anesthetized, kuvapo kwemukati kwakadziviswa zviri pachena ne decoctions.Asi kune imbwa dzine gastroenterostomy, ine imwe yekunakidza mhedzisiro, iyo inogona kuita gastrointestinal kufamba uye contraction rhythm ine simba.

3. Migumisiro pamwoyo uye tsinga dzeropa: zvishoma zvekunakidzwa uye hukuru hwekudzivisa pamwoyo wechucha in vitro.Fructus Aurantii uye Fructus Aurantii Aurantii aqueous decoction, Fructus Aurantii tincture, uye fluid yakabudiswa zvakafanana.Fructus Aurantii decoction kana doro rinobviswa jekiseni mukati memutsinga rinogona kuguma nekukosha kukuru kwekusimudzira.Fructus Aurantii uye Fructus Aurantii Fructus kubva kunzvimbo nhatu dzakasiyana dzakaratidzwa kuva dzakapfava vasoconstriction mhedzisiro nemuviri-yakazara vascular perfusion yematodhi.Mune imbwa dzeanesthetized, pakanga paine yakakosha uye nekukurumidza hypertension mhedzisiro.Pakanga pasina kuora mwoyo kwekufema kana hypotension yakakonzerwa ne epinephrine, uye pakanga pasina kuwedzera kuri pachena kwemoyo.

Iyo pressure-boosting mechanism ine chekuita nezvinhu zvinotevera:

3.1.Kuwedzeredza kwea α receptors, zvichikonzera vasoconstriction mune dzimwe nhengo (phenylzoline inogona kudzoreredza kumanikidza kuwedzera kuita antihypertensive reaction).

3.2.Yakasimbiswa myocardial contraction uye yakawedzera kubuda kwemoyo (yakasarudzika guinea yenguruve moyo perfusion uye cardiopulmonary kugadzirira).Mushure me reserpine, iyo yekumanikidza-inosimudzira mhedzisiro yeFructus aurantii aurantii yaive yakakosha.Yakanyanya kuwedzera coronary artery flow (289.4% yakawedzera coronary artery flow by bubble flowmeter) uye yakawedzera uropi uye itsvo kubuda kweropa ne86.4% uye 64.5% paavhareji, izvo zvaive zvakasiyana zvakanyanya nenorepinephrine.Paiva nekuderera kweropa rekuyerera kwechikadzi uye kuwedzera kuduku asi kuduku mumyocardial oxygen kushandiswa, iyo haina kupindirana nekuwedzera kukuru kwekoroni.Mukuedzwa kweECG mumbwa nenguruve, arrhythmia (ventricular tachycardia kana atrioventricular block) inokonzerwa nehombe huru yeaurantii aurantii yakanga isiri yakakomba.Zvichienderana nehunhu huri pamusoro, zvakakurudzirwa kurapa cardiogenic shock.Alkaloids yakaparadzaniswa kubva kuFructus Aurantii neLycium orenji inogonawo kuwedzera kwenguva pfupi kushushikana kwevascular smooth muscle, kunyanya kana yakarapwa nepituitrin.

4. Antithrombotic: In vitro test ye 0.1g / ml Fructus Aurantii aqua decoction yakaratidza pachena antithrombotic effect.

5. Anti-allergic reaction: 100mg / kg static pulse injection yeFructus Aurantii Aurantii mvura inobvisa inogona kudzivisa passive skin allergic reaction (PCA) mumakonzo, uye 50μg / ml inogona kudzivisa histamine kusunungurwa kubva kumakonzo emimba mast cells.

6. Mimwe migumisiro: Citrus plant mycin inogona kuderedza zvinyorwa zve cholestatin muserum uye chiropa chemakonzo anodyiswa nekudya kune cholesterol.Chinwiwa chedoro cheFructus Aurantii chine inhibitory effect pa mycobacterium tuberculosis H37Rv in vitro, uye inhibitory concentration yaive 1:1000.Yayo aqueous decoction yakanga isina simba pane guinea pig bronchus.Zvinonzi muto wecitrus unowedzera kuvirisa kwembiriso uye haudzikisi basa rayo mushure mekubikira, saka haisi enzymatic chikamu.Kunyanya kushandiswa pakurapa kwemuto weorenji ndeyekuti ine vhitamini C yakawanda uye ine A yakawanda yakawanda yevhitamini A uye B. Peel harina vhitamini C asi rine vhitamini A. Rinovava uye rinogona kusimbisa dumbu.Vana vakadai sekutora nhamba yakakura yemapeel vanogona kukonzera chepfu (marwadzo emudumbu, makumbo).

Chirevo: http://www.a-hospital.com

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