Chii chinonzi Shikimic Acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) chinhu chinongoitika chega chega chinova chakakosha chepakati mu biosynthesis ye lignin, anonhuwirira amino acids (phenylalanine, tyrosine uye tryptophan), uye mazhinji. chirimwa uye microbial alkaloids.

Shikimic acid inowanzoshandiswa sechinhu chekutanga chekugadzirwa kweindasitiri yeantiviral drug oseltamivir (mushonga unorwisa-H5N1 furuwenza hutachiona unoshandiswa kurapa nekudzivirira marudzi ese anozivikanwa ehutachiwana hwefuruwenza). Iyo synthesis ye (-) -zeylenone yakavakirwa paShikimic Acid inonzi inoshandiswa zvakanyanya semumiriri wekenza chemotherapy. Data inowanikwa pamusoro pezvakagadzirwa monopalmitoyloxy Shikimic Acid, iyo ine anticoagulant basa uye inokwanisa kuderedza ropa coagulability painoiswa intramuscularly. Chikwata chekuChina chekutsvagisa chakagadzira chinotorwa Shikimic Acid, triacetyl Shikimic Acid, inoratidza anticoagulant uye antithrombotic chiitiko.

Pamusoro pezvo, Shikimic Acid derivatives yakaratidza kufarira zvikuru zvekurima sezvo mazhinji acho achishandiswa semishonga yesora uye antimicrobial agents nekuti anogona kuvhara nzira yeShikimic Acid muzvirimwa nemabhakitiriya pasina kukanganisa mhuka dzinoyamwisa.

Saka, Shikimic Acid inogona kushandiswa seyakagadziriswa organic synthesis mune zvese zvekutanga sainzi uye zvekurapa zvikumbiro mune organic chemistry uye mushonga, kunyanya pakugadzirira kwemishonga yakasiyana.

Seyakakosha mishonga yemakemikari zvinhu, shikimic acid inogona kuiswa mukurapa kwezvirwere zvakawanda:

1. Antibacterial uye antitumor

Muna 1987, nyanzvi dzeJapan dzakaona kuti analog ye glyoxalase I inhibitor yakagadzirwa nemethyl anthranilate ine pachena inhibitory mhedzisiro paHela cell line uye Escheri ascites carcinoma, inogona kurebesa nguva yekupona kwemakonzo akaiswa neleukemia cell L1210, uye huturu hwakaderera. iyo inhibitory effect inonyanya kuenderana nesarufa hydride reaction. 1988, nyanzvi dzeChinese dzakaita Muna 1988, nyanzvi dzeChinese dzakagadzira shikimic acid inotorwa uye yakaratidza kuti komisheni iyi ine mhedzisiro yekuvharisa leukemia masero L1210 in vitro.

2. Anti-thrombosis

Mhedzisiro ye shikimic asidhi uye zvinobva kune yemoyo vascular system inoratidzwa mune basa reanti-thrombosis uye inhibition yeplatelet aggregation. Kutsvakurudza kunoratidza kuti: shikimic acid ine inhibitory inhibitory effect pa platelet aggregation rate ye adenosine diphosphate-induced middle cerebral artery embolism model rats; jekiseni re intravenous uye intramuscular ye shikimic acid rinogona kuita kuti nguva yekugwamba kweropa rembeva irebe.

3.Anti-cerebral ischemia

Shikimic acid uye zvinobva mairi zvine mhedzisiro yekuvandudza cerebral ischemia, kunyanya mukudzikisa huwandu hwecerebral infarction mushure meiyo focal cerebral ischemia mumakonzo, kuderedza uropi hwekuita basa, kuderedza chiyero checerebral edema, kuwedzera kuyerera kweropa munzvimbo yeischemic. nezvimwe zviratidzo. Zvimwe zvidzidzo zvakaratidza kuti zvinobva mairi zvinogona kuderedza chiyero che erythrocyte aggregation uye inhibit platelet aggregation mushure mecerebral ischemia, nokudaro kufambisa cerebral microcirculation.