Chii chinonzi Shikimic Acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) chinhu chinowanikwa zvakasikwa chiri chikamu chakakosha mukugadzirwa kwe lignin, amino acids anonhuhwirira (phenylalanine, tyrosine uye tryptophan), uye akawanda maalkaloids emiti nehutachiona.

Shikimic acid inowanzo shandiswa senzira yekutanga mukugadzirwa kwemushonga weantiviral oseltamivir (mushonga weH5N1 influenza virus unoshandiswa kurapa nekudzivirira marudzi ese anozivikanwa efuruwenza). Kugadzirwa kwe (-)-zeylenone kwakavakirwa paShikimic Acid kwakataurwa kuti kunoshandiswa zvakanyanya semushonga wekenza chemotherapy. Ruzivo rwuripo pamusoro pekugadzirwa kwemonopalmitoyloxy Shikimic Acid, ine anticoagulant activity uye inokwanisa kuderedza coagulability yeropa kana ikapinzwa mutsinga. Chikwata chekutsvagisa chekuChina chakagadzira Shikimic Acid derivative, triacetyl Shikimic Acid, iyo inoratidza anticoagulant uye antithrombotic activity.

Pamusoro pezvo, zvinhu zvinobva kuShikimic Acid zvakaratidza kufarira kukuru mukurima sezvo zvakawanda zvacho zvichishandiswa semishonga yekuuraya zvipembenene nemishonga inorwisa utachiona nekuti zvinogona kuvhara nzira yeShikimic Acid muzvirimwa nemabhakitiriya pasina kukanganisa mhuka dzinoyamwisa.

Saka, Shikimic Acid inogona kushandiswa se reactant yekugadzira organic muzvidzidzo zvesainzi uye zvekurapa mu organic chemistry nemishonga, kunyanya pakugadzirira mishonga yakasiyana-siyana.

Sechinhu chakakosha chemishonga, shikimic acid inogona kushandiswa pakurapa zvirwere zvakawanda:

1. Inorwisa mabhakitiriya uye inodzivirira bundu

Muna 1987, nyanzvi dzekuJapan dzakaona kuti analog ye glyoxalase I inhibitor inogadzirwa ne methyl anthranilate ine mhedzisiro yakajeka yekudzivirira pamutsetse wesero reHela neEscheri ascites carcinoma, inogona kuwedzera nguva yekurarama kwemakonzo akapihwa leukemia cell L1210, uye chepfu yacho yakaderera, mhedzisiro yayo yekudzivirira inonyanya kuenderana nekuita kwesulfur hydride. 1988, nyanzvi dzekuChina dzakaita Muna 1988, nyanzvi dzekuChina dzakagadzira shikimic acid derivative uye dzakaratidza kuti iyi compound ine mhedzisiro yekudzivirira masero eleukemia L1210 mu vitro.

2. Kurwisa thrombosis

Kushanda kwe shikimic acid nezvimwe zvinobva mairi pamwoyo kunoratidzwa mukushanda kwekudzivirira thrombosis uye kudzivirira kuunganidzwa kweplatelet. Tsvagiridzo inoratidza kuti: shikimic acid ine simba guru rekudzivirira kuunganidzwa kweplatelet yemakonzo e adenosine diphosphate-induced middle cerebral artery embolism; kubayiwa kwe shikimic acid mutsinga nepamutsinga kunogona kuita kuti nguva yekugwamba kweropa remakonzo irebe.

3. Kurwisa kushaikwa kweropa muuropi

Shikimic acid nezvimwe zvinobva mairi zvine simba rekuvandudza cerebral ischemia, kunyanya mukuderedza huwandu hwe cerebral infarction mushure me focal cerebral ischemia mumakonzo, kuderedza function score yetsinga, kuderedza mwero we cerebral edema, kuwedzera kuyerera kweropa muuropi munzvimbo ye ischemic nezvimwe zviratidzo. Dzimwe ongororo dzakaratidza kuti zvinobva mairi zvinogona kuderedza mwero we erythrocyte aggregation uye kudzivirira platelet aggregation mushure me cerebral ischemia, nokudaro zvichiita kuti cerebral microcirculation ishande zvakanaka.